ReviewBrazilian journal of anesthesiology (Elsevier)
[Peripheral nerve block and rebound pain: literature review].
Review in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06431906 (TRANSDERMAL FENTANYL AS A FORM OF REBOUND PAIN REDUCTION IN FAST TRACK PROGRAMME IN PRIMARY KNEE ARTHROPLASTY. Prospective Observational Non-inferiority Study Versus Morphine PCA.), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TRANSDERMAL FENTANYL AS A FORM OF REBOUND PAIN REDUCTION IN FAST TRACK PROGRAMME IN PRIMARY KNEE ARTHROPLASTY. Prospective Observational Non-inferiority Study Versus Morphine PCA.
Who cites it
26 citing papers in PubMed.
- Effect of Perioperative Intravenous Lidocaine on Rebound Pain After Interscalene Brachial Plexus Block for Arthroscopic Rotator Cuff Repair: A Randomized Placebo-Controlled Trial.Drug design, development and therapy · 2026Trial
- S-Ketamine Reduces the Risk of Rebound Pain in Patients Following Total Knee Arthroplasty: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Erector Spinae Plane (ESP) Block for Postoperative Pain Management after Open Oncologic Abdominal Surgery.Pain research & management · 2023Trial
- Effect of Transauricular Vagus Nerve Stimulation on Rebound Pain After Ropivacaine Single Injection Femoral Nerve Block for Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial.Journal of pain research · 2022Trial
- Supraclavicular block with Mepivacaine vs Ropivacaine, their impact on postoperative pain: a prospective randomised study.BMC anesthesiology · 2021Trial
- Evaluation of Postblock Hypersensitivity Using Quantitative Sensory Testing before, during, and after Axillary Brachial Plexus Block Resolution in Healthy Volunteers.Anesthesiology · 2026Article
- Factors associated with postoperative rebound pain after peripheral nerve block anaesthesia for orthopedic trauma surgery: a retrospective cohort analysis.Journal of orthopaedic surgery and research · 2025Article
- Efficacy of Erector Spinae Plane Block for Pain Management after Hip Surgery: A Narrative Review.Current pain and headache reports · 2025Review
- Rebound Pain-Management Strategies for Transitional Analgesia: A Narrative Review.Journal of clinical medicine · 2025Review
- Effect of Intravenous Esketamine on Rebound Pain Following Single-Shot Brachial Plexus Block in Patients Undergoing Shoulder Arthroscopic Surgery: A Prospective, Randomized, Placebo-Controlled Study.Journal of pain research · 2025Article
- Risk Factors for the Occurrence of Rebound Pain After Intercostal Nerves Block in Three-Port Thoracoscopic Surgery: A Case-Control Study.Journal of pain research · 2025Article
- Enhancing Pain Management and Psychological Recovery in Earthquake Victims: The Role of Continuous Regional Analgesic Techniques Assessed by QoR-15.Diagnostics (Basel, Switzerland) · 2024Article
- Prevention and management of rebound pain after resolution of regional block: a systematic review.Annals of medicine and surgery (2012) · 2024Review
- Article
- Clinical value of esketamine combined with ropivacaine in rebound pain after brachial plexus block in patients with upper limb fractures.Frontiers in surgery · 2024Article
- The Effects of Intraoperative Remifentanil Infusion on Postoperative Opioid Consumption in Patients Who Underwent Total Knee Arthroplasty with Femoral Nerve Block.Journal of clinical medicine · 2023Article
- Pain Management and Functional Recovery after Pericapsular Nerve Group (PENG) Block for Total Hip Arthroplasty: A Prospective, Randomized, Double-Blinded Clinical Trial.Journal of clinical medicine · 2023Article
- Article
- Pericapsular Nerves Group (PENG) Block in Children under Five Years of Age for Analgesia in Surgery for Hip Dysplasia: Case Report.Journal of personalized medicine · 2023Article
- Effects of esketamine on postoperative rebound pain in patients undergoing unilateral total knee arthroplasty: a single-center, randomized, double-blind, placebo-controlled trial protocol.Frontiers in neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesTo investigate, describe, and assess the phenomenon of "rebound pain" as a clinically relevant problem in anesthetic practice. CONTENT: The phenomenon of "rebound pain" has been demonstrated and described as a very severe pain, which occurs after a peripheral nerve block resolution with the recovery of sensitivity. The incidence of rebound pain is unknown. Usually, it occurs between 12 to 24hours after surgery and adversely affecting sleep quality. It is not yet possible to establish a mechanism as a definitive cause or trigger factor of rebound pain. Studies suggest that rebound pain is a side effect of peripheral nerve blocks, despite their effectiveness in pain control. Currently, the extent and clinical significance of rebound pain cannot be well determined due to the lack of large prospective studies.
conclusionRebound pain assessment should always be considered in clinical practice, as it is not a rare side effect of peripheral nerve blocks. There are still many challenging questions to be answered about rebound pain, so large prospective studies are needed to address the issue. For prevention, the use of peripheral nerve block techniques that avoid nerve damage and adequate perioperative analgesia associated with patient education on the early administration of analgesics, even during the period of analgesia provided by peripheral nerve block, is recommended. A better understanding of the "rebound pain" phenomenon, its pathophysiology, associated risk factors, and long-term consequences may help in developing more effective preventive strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.