SynthesisBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Meta-analysis of Structural Magnetic Resonance Imaging Studies in Pediatric Posttraumatic Stress Disorder and Comparison With Related Conditions.
Synthesis in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Structural brain correlates in major depressive disorder, anxiety disorders, and post-traumatic stress disorder: a diffusion tensor imaging meta-analysis.Psychological medicine · 2025Pooled it
- A meta-analysis of the relation between hippocampal volume and memory ability in typically developing children and adolescents.Hippocampus · 2022Pooled it
- Altered triple network model connectivity is associated with cognitive function and depressive symptoms in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Differential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females.Scientific reports · 2025Article
- Working memory performance is related to childhood trauma but not psychotic-like experiences in a nonpsychiatric sample.Psychological trauma : theory, research, practice and policy · 2024Article
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field.Molecular psychiatry · 2024Review
- Smaller Hippocampal Volume Is Associated With Reduced Posttraumatic Stress Symptoms in Children With Cancer and Survivors Following a Brief Novel Martial Arts-Based Intervention.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- A stable and replicable neural signature of lifespan adversity in the adult brain.Nature neuroscience · 2023Article
- Brain morphometry points to emerging patterns of psychosis, depression, and anxiety vulnerability over a 2-year period in childhood.Psychological medicine · 2023Article
- Characteristics of white matter structural connectivity in healthy adults with childhood maltreatment.European journal of psychotraumatology · 2023Article
- Neurostructural associations with traumatic experiences during child- and adulthood.Translational psychiatry · 2022Article
- Sex-based variations of prefrontal structure and longitudinal symptoms in pediatric posttraumatic stress disorder.Depression and anxiety · 2022Article
- Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.The American psychologist · 2022Article
- Reduced structural connectivity of the amygdala is associated with childhood trauma in adult patients with alcohol use disorder.Addiction biology · 2022Article
- The relationship between recent PTSD secondary to sexual assault, hippocampal volume and resting state functional connectivity in adolescent girls.Neurobiology of stress · 2022Article
- Subclinical Anxiety and Posttraumatic Stress Influence Cortical Thinning During Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Migration-related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policy.Developmental psychobiology · 2021Review
- Changes in Brain Volume Associated with Trauma-Focused Cognitive Behavioral Therapy Among Youth with Posttraumatic Stress Disorder.Journal of traumatic stress · 2021Article
- Gray matter volume correlates of adolescent posttraumatic stress disorder: A comparison of manual intervention and automated segmentation in FreeSurfer.Psychiatry research. Neuroimaging · 2021Article
- Safety learning during development: Implications for development of psychopathology.Behavioural brain research · 2021Review
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundFindings on structural brain volume associated with pediatric posttraumatic stress disorder (PTSD) have been variable, and it is unclear whether any structural differences are specific to pediatric PTSD in comparison with adult PTSD or other co-occurring pediatric psychiatric conditions.
methodsWe tested volumetric brain differences between pediatric groups with and without PTSD in a region-of-interest meta-analysis. We conducted meta-regressions to test the effects of age and sex on heterogeneous study findings. To assess specificity, we compared pediatric PTSD with the following: adult PTSD, pediatric trauma exposure without PTSD, pediatric depression, and pediatric anxiety.
resultsIn 15 studies examined, pediatric PTSD was associated with smaller total gray matter and cerebral, temporal lobe (total, right, and left), total cerebellar vermis, and hippocampal (total, right, and left) volumes, compared to peers without PTSD. In the pediatric PTSD group, but not the comparison group, we found a trend toward smaller total, right, and left amygdalar volumes. In an external comparison, smaller hippocampal volume was not significantly different between adult and pediatric PTSD groups. Qualitative comparisons with a pediatric trauma exposure without PTSD group, a pediatric depression group, and a pediatric anxiety group revealed differences that may be unique to pediatric PTSD, and others that may be convergent with these related clinical conditions in youth.
conclusionsPediatric PTSD is associated with structural differences that parallel those associated with adult PTSD. Furthermore, pediatric PTSD appears to be distinct from other related pediatric conditions at the structural level. Future studies employing longitudinal, dimensional, and multimodal neuroimaging approaches will further elucidate the nature of neurobiological differences in pediatric PTSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.