ArticleBiological psychiatry2020
Neurostructural Heterogeneity in Youths With Internalizing Symptoms.
Article in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Systematic Review of Functional MRI Applications for Psychiatric Disease Subtyping.Frontiers in psychiatry · 2021Pooled it
- Neuroanatomical Subtypes of Callous-Unemotional Traits in a Community Sample of Youth.bioRxiv : the preprint server for biology · 2026Article
- Neurobiological subtypes in alcohol use disorder and their phenotypic and clinical profiles.Molecular psychiatry · 2026Article
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- Connectivity between the central executive and salience networks normalizes with exposure-focused CBT in pediatric anxiety.medRxiv : the preprint server for health sciences · 2026Article
- Dissecting real-world memory clinical cohort heterogeneity: analysis of neuroanatomical subtypes using HYDRA.Alzheimer's research & therapy · 2025Article
- Prospective Relations between Cortical Thickness and Change in Internalizing Symptoms are Moderated by Chronic Stress Exposure in Adolescents with Depression and Anxiety.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Beyond out-of-sample: robust and generalizable multivariate neuroanatomical patterns of psychiatric problems in youth.Molecular psychiatry · 2025Article
- Parsing the heterogeneity of depression: a data-driven subgroup derived from cognitive function.Frontiers in psychiatry · 2025Article
- Structural Brain Correlates of Anxiety During Development.Current topics in behavioral neurosciences · 2025Review
- Using machine learning to derive neurobiological subtypes of general psychopathology in late childhood.Journal of psychopathology and clinical science · 2024Article
- Dimensional Neuroimaging Endophenotypes: Neurobiological Representations of Disease Heterogeneity Through Machine Learning.Biological psychiatry · 2024Review
- Intracortical Myelin in Youths at Risk for Depression.Biological psychiatry global open science · 2024Article
- Article
- Development and application of novel performance validity metrics for computerized neurocognitive batteries.Journal of the International Neuropsychological Society : JINS · 2023Article
- Managing Cancer and Living Meaningfully (CALM) alleviates chemotherapy related cognitive impairment (CRCI) in breast cancer survivors: A pilot study based on resting-state fMRI.Cancer medicine · 2023Article
- Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium.Molecular psychiatry · 2023Article
- Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders.Molecular psychiatry · 2023Article
- Modern views of machine learning for precision psychiatry.Patterns (New York, N.Y.) · 2022Review
- Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes.Biological psychiatry · 2022Article
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Authors and funding
20 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundInternalizing disorders such as anxiety and depression are common psychiatric disorders that frequently begin in youth and exhibit marked heterogeneity in treatment response and clinical course. Given that symptom-based classification approaches do not align with underlying neurobiology, an alternative approach is to identify neurobiologically informed subtypes based on brain imaging data.
methodsWe used a recently developed semisupervised machine learning method (HYDRA [heterogeneity through discriminative analysis]) to delineate patterns of neurobiological heterogeneity within youths with internalizing symptoms using structural data collected at 3T from a sample of 1141 youths.
resultsUsing volume and cortical thickness, cross-validation methods indicated 2 highly stable subtypes of internalizing youths (adjusted Rand index = 0.66; permutation-based false discovery rate p < .001). Subtype 1, defined by smaller brain volumes and reduced cortical thickness, was marked by impaired cognitive performance and higher levels of psychopathology than both subtype 2 and typically developing youths. Using resting-state functional magnetic resonance imaging and diffusion images not considered during clustering, we found that subtype 1 also showed reduced amplitudes of low-frequency fluctuations in frontolimbic regions at rest and reduced fractional anisotropy in several white matter tracts. In contrast, subtype 2 showed intact cognitive performance and greater volume, cortical thickness, and amplitudes during rest compared with subtype 1 and typically developing youths, despite still showing clinically significant levels of psychopathology.
conclusionsWe identified 2 subtypes of internalizing youths differentiated by abnormalities in brain structure, function, and white matter integrity, with one of the subtypes showing poorer functioning across multiple domains. Identification of biologically grounded internalizing subtypes may assist in targeting early interventions and assessing longitudinal prognosis.
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