ArticleEnvironmental health : a global access science source2019
Determinants of arsenic methylation efficiency and urinary arsenic level in pregnant women in Bangladesh.
Article in Environmental health : a global access science source, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults.The Cochrane database of systematic reviews · 2021Pooled it
- Arsenome, Arsenobolome, and Arsenobiolome.International journal of molecular sciences · 2025Review
- Quantitation of Arsenic in biological matrices: Use of Sector Field Inductively Coupled Plasma-Mass Spectrometry for Improved Accuracy and Specificity.Analytical letters · 2025Article
- Arsenic Methyltransferase and Apolipoprotein E Polymorphism in Pregnant Women Exposed to Inorganic Arsenic in Drinking Water in Western Romania.International journal of molecular sciences · 2024Article
- Association between Arsenic Methylation in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study.Environment & health (Washington, D.C.) · 2023Article
- Biomonitoring of inorganic arsenic species in pregnancy.Journal of exposure science & environmental epidemiology · 2023Review
- Altered cord blood mitochondrial DNA content and prenatal exposure to arsenic metabolites in low-arsenic areas.Research square · 2023Article
- Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh.Environmental research · 2023Article
- Comparative Biomonitoring of Arsenic Exposure in Mothers and Their Neonates in Comarca Lagunera, Mexico.International journal of environmental research and public health · 2022Article
- Alterations in Microbial-Associated Fecal Metabolites in Relation to Arsenic Exposure Among Infants.Exposure and health · 2022Article
- Maternal serum concentrations of one-carbon metabolism factors modify the association between biomarkers of arsenic methylation efficiency and birth weight.Environmental health : a global access science source · 2022Article
- Household use of crop residues and fuelwood for cooking and newborn birth size in rural Bangladesh.Occupational and environmental medicine · 2022Article
- Umbilical Cord Blood Metal Mixtures and Birth Size in Bangladeshi Children.Environmental health perspectives · 2021Article
- As3MT and GST Polymorphisms Influencing Arsenic Metabolism in Human Exposure to Drinking Groundwater.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundPrenatal inorganic arsenic (iAs) exposure is associated with pregnancy outcomes. Maternal capabilities of arsenic biotransformation and elimination may influence the susceptibility of arsenic toxicity. Therefore, we examined the determinants of arsenic metabolism of pregnant women in Bangladesh who are exposed to high levels of arsenic.
methodsIn a prospective birth cohort, we followed 1613 pregnant women in Bangladesh and collected urine samples at two prenatal visits: one at 4-16 weeks, and the second at 21-37 weeks of pregnancy. We measured major arsenic species in urine, including iAs (iAs%) and methylated forms. The proportions of each species over the sum of all arsenic species were used as biomarkers of arsenic methylation efficiency. We examined the difference in arsenic methylation using a paired t-test between first and second visits. Using linear regression, we examined determinants of arsenic metabolism, including age, BMI at enrollment, education, financial provider income, arsenic exposure level, and dietary folate and protein intake, adjusted for daily energy intake.
resultsComparing visit 2 to visit 1, iAs% decreased 1.1% (p < 0.01), and creatinine-adjusted urinary arsenic level (U-As) increased 21% (95% CI: 15, 26%; p < 0.01). Drinking water arsenic concentration was positively associated with iAs% at both visits. When restricted to participants with higher adjusted urinary arsenic levels (adjusted U-As > 50 μg/g-creatinine) gestational age at measurement was strongly associated with DMA% (β = 0.38, p < 0.01) only at visit 1. Additionally, DMA% was negatively associated with daily protein intake (β = - 0.02, p < 0.01) at visit 1, adjusting for total energy intake and other covariates.
conclusionsOur findings indicate that arsenic metabolism and adjusted U-As level increase during pregnancy. We have identified determinants of arsenic methylation efficiency at visit 1.
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