Evidence map›Paper›PMID 31690338›Full record

ArticleGenome biology2019

Mash Screen: high-throughput sequence containment estimation for genome discovery.

Brian D Ondov, Gabriel J Starrett, Anna Sappington, Aleksandra Kostic, Sergey Koren, Christopher B Buck, Adam M Phillippy

Abstract read
In one paragraph

Article in Genome biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers.

0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

193 citing papers in PubMed.

  1. Complete genome sequence ofMicrobiology resource announcements · 2026
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  3. Draft genome ofMicrobiology resource announcements · 2026
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  4. Draft genomes ofMicrobiology resource announcements · 2026
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  7. Sequencing the genome ofMicrobiology resource announcements · 2026
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  8. Estimation of substitution and indel rates via k-mer statistics.Algorithms for molecular biology : AMB · 2026
    Article
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  15. Article
  16. Article
  17. Deconvolving Phylogenetic Distance Mixtures.bioRxiv : the preprint server for biology · 2026
    Article
  18. Article
  19. Article
  20. Complete genome sequence ofMicrobiology resource announcements · 2026
    Article

133 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brian D OndovGenome Informatics section, National Human Genome Research Institute, Bethesda, MD, USA. brian.ondov@nih.gov.ORCID 0000-0002-0740-1793
Gabriel J StarrettTumor Virus Molecular Biology section, National Cancer Institute, Bethesda, MD, USA.
Anna SappingtonDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Aleksandra KosticDepartment of Computer Science, Princeton University, Princeton, NJ, USA.
Sergey KorenGenome Informatics section, National Human Genome Research Institute, Bethesda, MD, USA.
Christopher B BuckTumor Virus Molecular Biology section, National Cancer Institute, Bethesda, MD, USA.
Adam M PhillippyGenome Informatics section, National Human Genome Research Institute, Bethesda, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The MinHash algorithm has proven effective for rapidly estimating the resemblance of two genomes or metagenomes. However, this method cannot reliably estimate the containment of a genome within a metagenome. Here, we describe an online algorithm capable of measuring the containment of genomes and proteomes within either assembled or unassembled sequencing read sets. We describe several use cases, including contamination screening and retrospective analysis of metagenomes for novel genome discovery. Using this tool, we provide containment estimates for every NCBI RefSeq genome within every SRA metagenome and demonstrate the identification of a novel polyomavirus species from a public metagenome.

Indexed as

DNA ContaminationHigh-Throughput Screening AssaysAlgorithmsHumansMetagenomicsPolyomavirusProteomeProteomeMetagenomicsMinHashPolyomavirusSequencingSRAViral Discovery

Identifiers

PMID31690338
PMCPMC6833257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.