ArticleAnnals of clinical microbiology and antimicrobials2019
Exploring the phenotype and genotype of multi-drug resistant Klebsiella pneumoniae harbouring bla
Article in Annals of clinical microbiology and antimicrobials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Molecular epidemiological analysis of blaAnnals of clinical microbiology and antimicrobials · 2024Article
- Levels of Different Microbial Groups on Inert Surfaces of Poultry Slaughterhouses: Identification Using Matrix-Assisted Laser Desorption Ionization Time-of-Flight and Detection of Extended-Spectrum Beta-Lactamase- and Carbapenemase-Producing Enterobacteria.Antibiotics (Basel, Switzerland) · 2024Article
- Phenotypic and Molecular Characterization of Hypervirulent and Multidrug-ResistantThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024Article
- Pandemic one health clones ofFrontiers in cellular and infection microbiology · 2023Article
- Antimicrobial Resistance Patterns, Sequence Types, Virulence and Carbapenemase Genes of Carbapenem-ResistantInfection and drug resistance · 2023Article
- Geno- and Phenotypic Characteristics of aMicroorganisms · 2022Article
- Genetic Characterization of Colistin-ResistantInfection and drug resistance · 2022Article
- Genome-Based Analysis ofPathogens (Basel, Switzerland) · 2021Article
- Clonal Dissemination of Multiple Carbapenemase Genes in Carbapenem-Resistant Enterobacterales Mediated by Multiple Plasmids in China.Infection and drug resistance · 2021Article
- FecalFrontiers in microbiology · 2020Article
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3 authors.
Funding
Abstract
backgroundEmergence and spread of β-lactamase resistant Klebsiella pneumoniae have posed a serious threat, especially in paediatric patients globally. The present study focuses on explore drug resistance profile and molecular characterization of carbapenemase and extended-spectrum β-lactamase producing K. pneumoniae isolated from paediatric patients in Shenzhen, China.
methodsPresent study, a total of 31 isolates of multi-drug resistant K. pneumoniae were collected from Shenzhen Children's Hospital, China during Jan 2014 to December 2015. ESBLs production was confirmed by using the combination disc diffusion method followed by antimicrobial susceptibility. In addition, β-lactamase encoding genes were determined by PCR assay and sequencing. The genotypic diversity and phylogenetic relationship were determined by multi-locus sequence typing (MLST) method and pulsed-field gel electrophoresis (PFGE).
resultsWe examined 31, unique K. pneumoniae isolates collected from 2014 and 2015 in Shenzhen Children's Hospital, China. All the 31 isolates 100% were resistant to ceftazidime, ertapenem, ampicillin, cefazolin and ampicillin-sulbactam followed by ceftriaxone 94% (n = 29), aztreonam 89% (n = 26), cefepime 84% (n = 26), nitrofurantoin 75% (n = 24), piperacillin 52% (n = 16), and levofloxacin 49% (n = 15). Of the 31 β-lactamase gene coding isolates, bla
conclusionOur study reports the occurrence and spread of extended β-lactamase K. pneumoniae ST20 and ST2407 for the first time, in Shenzhen, particularly in paediatric patients. To prevent and control the infection by limiting the spread of infection-causing organisms it is very crucial to detect the presence of resistant genes at an early stage.
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