Observational studyBMC pediatrics2019
Efficiency and safety of phenylephrine and tropicamide used in premature retinopathy: a prospective observational study.
Observational study in BMC pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03448640 (Efficiency and Safety of Phenylephrine and Tropicamide Used in Premature Retinopathy), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficiency and Safety of Phenylephrine and Tropicamide Used in Premature Retinopathy
Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- A Small-Volume Topical Ophthalmic Spray for Pupillary Dilation in Children: A Randomized, Masked, Noninferiority Trial.Ophthalmology · 2026Trial
- Comparison of microdrop administration using a bottle adapter of 2.5% phenylephrine and 0.8% tropicamide with standard drop for ROP examination: a randomized controlled noninferiority trial.Maternal health, neonatology and perinatology · 2026Article
- Physiological responses to retinopathy of prematurity screening: indirect ophthalmoscopy versus ultra-widefield retinal imaging.Pediatric research · 2025Article
- Incidence and risk factors of retinopathy of prematurity in Palestine: a retrospective cohort study, 2024.BMC ophthalmology · 2025Article
- Heart failure temporally associated with tropicamide and phenylephrine eye drops in a premature infant: A case report and literature review.SAGE open medical case reports · 2025Article
- Implications of Ocular Confounding Factors for Aqueous Humor Proteomic and Metabolomic Analyses in Retinal Diseases.Translational vision science & technology · 2024Article
- The effects of mydriatic eye drops on cerebral blood flow and oxygenation in retinopathy of prematurity examinations.European journal of pediatrics · 2023Article
- Acute drug reaction to phenylephrine and tropicamide collyrium in a late-preterm newborn: a case report.BMC pediatrics · 2022Article
- Brazilian guideline for pediatric cycloplegia and mydriasis.Arquivos brasileiros de oftalmologiaArticle
- Tropicamide and anaphylaxis: A case report.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine effects and side effects of topical application of phenylephrine 2.5% and tropicamide 0.5% combination in preterm infants.
methodsIn this prospective observational study, 60 infants undergoing retinopathy of prematurity (ROP) screening were prospectively observed. Pupillary diameter, blood pressure, heart rate, and oxygen saturation were monitored before and after up to 24 h during ROP screening examinations.
resultsThe mean pupillary diameter 1 h after the instillation of drops was 5.58 ± 0.75 mm for both eyes. The mean systolic and diastolic pressure and oxygen saturation of infants did not change statistically until the end of the study. The average heart rate decreased by a mean of 4.96 beats/minute from the baseline following eye drops instillation. General condition deterioration, fall in oxygen saturation and bradycardia were observed in 4 infants that already had respiratory distress syndrome.
conclusionThe phenylephrine 2.5% plus tropicamide 0.5% drop is effective and safe as mydriatic combination for retinopathy of prematurity screening. In infants with an additional systemic disease such as respiratory distress syndrome, the side effects of mydriatic drops may be more common. Such babies should be kept under close observation.
trial registrationThe trial was retrospectively registered on 28 February 2018. The ClinicalTrials.gov Identifier is NCT03448640.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.