Evidence map›Paper›PMID 31689948›Full record

ArticleJournal of clinical medicine2019

Involution of Breast Lobules, Mammographic Breast Density and Prognosis Among Tamoxifen-Treated Estrogen Receptor-Positive Breast Cancer Patients.

Maeve Mullooly, Sarah J Nyante, Ruth M Pfeiffer, Renata Cora, Donna Butcher, Lawrence Sternberg, Erin J Aiello Bowles, Shaoqi Fan, Jonine D Figueroa, Sheila Weinmann and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Maeve MulloolyDivision of Population Health Sciences, Royal College of Surgeons in Ireland, D02 YN77 Dublin, Ireland. maevemullooly@rcsi.ie.
Sarah J NyanteDepartment of Radiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. sarah_nyante@med.unc.edu.
Ruth M PfeifferDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. pfeiffer@mail.nih.gov.ORCID 0000-0001-7791-2698
Renata CoraIndependent Contractor, CT(ASCP), MB(ASCP), Stamford, CT 06901, USA. renata.cora@nih.gov.ORCID 0000-0001-5103-1278
Donna ButcherPathology-Histotechnology Laboratory, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD 21702, USA. butcherdo@mail.nih.gov.
Lawrence SternbergPathology-Histotechnology Laboratory, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD 21702, USA. sternberglr@mail.nih.gov.
Erin J Aiello BowlesKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA. Erin.A.Bowles@kp.org.
Shaoqi FanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. shaoqi.fan@nih.gov.ORCID 0000-0001-5894-7510
Jonine D FigueroaUsher Institute of Population Health Sciences and Informatics, CRUK Edinburgh Centre, Medical School, The University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK. jonine.figueroa@ed.ac.uk.
Sheila WeinmannKaiser Permanente Northwest Center for Health Research, Portland, OR 97227, USA. Sheila.Weinmann@kpchr.org.
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. hooverr@exchange.nih.gov.
Louise A BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. brintonl@exchange.nih.gov.
Amy Berrington de GonzalezDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. berringtona@mail.nih.gov.
Andrew GlassKaiser Permanente Northwest Center for Health Research, Portland, OR 97227, USA. andy_5241@msn.com.
Mark E ShermanMayo Clinic, Jacksonville, FL 32224, USA. Sherman.Mark@mayo.edu.
Gretchen L GierachDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. gierachg@mail.nih.gov.
National Cancer Institute · USFrederick National Laboratory for Cancer Research · USKaiser Permanente Center for Health Research · USKaiser Permanente Washington Health Research Institute · USRoyal College of Surgeons in Ireland · IEUniversity of Edinburgh · GBUniversity of North Carolina at Chapel Hill · USWinnMed · US

Funding

Group Health Cancer Research Program Research Specialist AwardR50CA211115 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI BOWLES, ERIN JANELLE AIELLO · 2017 to 2021
$919k
Health Research Board in Ireland CPFPR-2013-1Intramural Research Program of the National Cancer Institute at the National Institutes of Health NCI-funded contracts HHSN261200-900017C and HHSN261201-200304PNCI NIH HHS R50 CA211115
6 · The paper itself

Abstract

Mammographic breast density (MD) reflects breast fibroglandular content. Its decline following adjuvant tamoxifen treated, estrogen receptor (ER)-positive breast cancer has been associated with improved outcomes. Breast cancers arise from structures termed lobules, and lower MD is associated with increased age-related lobule involution. We assessed whether pre-treatment involution influenced associations between MD decline and risk of breast cancer-specific death. ER-positive tamoxifen treated patients diagnosed at Kaiser Permanente Northwest (1990-2008) were defined as cases who died of breast cancer (

Indexed as

breast cancerinvolutionmammographic breast densityterminal duct lobular unit

Identifiers

PMID31689948
PMCPMC6912285
OpenAlexW2985948531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.