SynthesisMedicine2019
Association between prenatal exposure to bisphenol a and birth outcomes: A systematic review with meta-analysis.
Synthesis in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic evidence map on the association between exposure to personal care products and fetal growth.Environment international · 2026Pooled it
- Bisphenol A and human fertility: a systematic review.JBRA assisted reproduction · 2025Pooled it
- Gestational Exposure to 10 Classes of Priority Chemicals and Birth Outcomes in the ECHO Cohort.JAMA network open · 2026Article
- Prenatal Exposure to Mixtures of Nonpersistent Endocrine-Disrupting Chemicals and Angiogenic Biomarkers, Placental Function, and Fetal Growth.Environmental science & technology · 2026Article
- Childhood Obesity: A Narrative Review.Cureus · 2025Review
- Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort.Environmental health : a global access science source · 2025Article
- Advancing Understanding of Chemical Exposures and Maternal-child Health Through the U.S. Environmental Influences on Child Health Outcomes (ECHO) Program: A Scoping Review.Current environmental health reports · 2024Article
- Sex-Specific Associations between Prenatal Exposure to Bisphenols and Phthalates and Infant Epigenetic Age Acceleration.Epigenomes · 2024Article
- Prenatal exposure to environmental phenols and phthalates and altered patterns of DNA methylation in childhood.Environment international · 2024Article
- Association between pre- and postnatal exposure to endocrine-disrupting chemicals and birth and neurodevelopmental outcomes: an extensive review.Clinical and experimental pediatrics · 2024Article
- The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies.International journal of molecular sciences · 2024Review
- The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study.Frontiers in public health · 2024Article
- Prenatal Phenol and Paraben Exposures and Adverse Birth Outcomes: A Prospective Analysis of U.S. Births.Environment international · 2024Article
- Prenatal Exposure to Bisphenol A: Is There an Association between Bisphenol A in Second Trimester Amniotic Fluid and Fetal Growth?Medicina (Kaunas, Lithuania) · 2023Article
- Maternal urinary bisphenols and phthalates in relation to estimated fetal weight across mid to late pregnancy.Environment international · 2023Article
- Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction.Biomedicines · 2023Review
- Environmental toxicants and placental function.Best practice & research. Clinical obstetrics & gynaecology · 2022Review
- Cytogenetic and developmental toxicity of bisphenol A and bisphenol S in Arbacia lixula sea urchin embryos.Ecotoxicology (London, England) · 2022Article
- The association of prenatal exposure to benzophenones with gestational age and offspring size at birth.Environmental science and pollution research international · 2022Article
- Association of maternal exposure to bisphenol A with her β-hCG level and neonatal anthropometric measures.Environmental science and pollution research international · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies investigated the relation of prenatal exposure to bisphenol A (BPA) and birth outcomes, but these results were inconsistent. The aim of this study was to investigate the relation of prenatal exposure to BPA and birth outcomes, provide comprehensive results based on current studies.
methodsThe PubMed, Cochrane databases, and Web of Science databases were searched systematically by two researchers respectively from their inceptions to Oct. 2018, using the following keywords "bisphenol A, birth weight, birth length, head circumference, gestational age, birth outcomes". We extracted β coefficient and 95% confidence interval (CI) or β coefficient and standard deviation (SD) from included study. The subgroup analysis was performed to evaluate the potential heterogeneity between studies. We conducted sensitivity analysis by excluding the each individual study to assess the results whether were stable. Finally, the publication bias was performed by accumulative forest plot.
resultsSeven studies with 3004 participants met the inclusion criteria. BPA had significant positively association with birth weight (β = 21.92, 95%CI: 1.50-42.35, P = .04). No significant associations were found between BPA and birth length, head circumference and gestational age (All of P > .05).
conclusionThis meta-analysis demonstrated that the BPA was positively associated with birth weight. Therefore, further studies are needed to investigate the critical sensitive period of influencing fetal development and to investigate the difference on gender.
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Registered trials
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