Evidence map›Paper›PMID 31689713›Full record

ArticleThe Journal of clinical endocrinology and metabolism2020

Evidence for Accelerated Biological Aging in Young Adults with Prader-Willi Syndrome.

Stephany H Donze, Veryan Codd, Layla Damen, Wesley J Goedegebuure, Matthew Denniff, Nilesh J Samani, Janiëlle A E M van der Velden, Anita C S Hokken-Koelega

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Stephany H DonzeDutch Growth Research Foundation, Rotterdam, The Netherlands.
Veryan CoddDepartment of Cardiovascular Sciences, University of Leicester, NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.
Layla DamenDutch Growth Research Foundation, Rotterdam, The Netherlands.
Wesley J GoedegebuureDepartment of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.
Matthew DenniffDepartment of Cardiovascular Sciences, University of Leicester, NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.
Janiëlle A E M van der VeldenDepartment of Pediatrics, Subdivision of Endocrinology, Radboud University Medical Centre-Amalia Children's Hospital, Nijmegen, The Netherlands.
Anita C S Hokken-KoelegaDutch Growth Research Foundation, Rotterdam, The Netherlands.
Erasmus MC · NLUniversity of Leicester · GBRadboud University Nijmegen · NL

Funding

Medical Research Council MR/M012816/1
6 · The paper itself

Abstract

objectiveAdults with Prader-Willi syndrome (PWS) are at increased risk of developing age-associated diseases early in life and, like in premature aging syndromes, aging might be accelerated. We investigated leukocyte telomere length (LTL), a marker of biological age, in young adults with PWS and compared LTL to healthy young adults of similar age. As all young adults with PWS were treated with growth hormone (GH), we also compared LTL in PWS subjects to GH-treated young adults born short for gestational age (SGA).

designCross-sectional study in age-matched young adults; 47 with PWS, 135 healthy, and 75 born SGA. MEASUREMENTS: LTL measured by quantitative polymerase chain reaction, expressed as telomere/single copy gene ratio.

resultsMedian (interquartile range) LTL was 2.6 (2.4-2.8) at a median (interquartile range) age of 19.2 (17.7-21.3) years in PWS, 3.1 (2.9-3.5) in healthy young adults and 3.1 (2.8-3.4) in the SGA group. Median LTL in PWS was significantly lower compared to both control groups (P < .01). In PWS, a lower LTL tended to be associated with a lower total IQ (r = 0.35, P = .08). There was no association between LTL and duration of GH treatment, cumulative GH dose, or several risk factors for type 2 diabetes mellitus or cardiovascular disease.

conclusionsYoung adults with PWS have significantly shorter median LTL compared to age-matched healthy young adults and GH-treated young adults born SGA. The shorter telomeres might play a role in the premature aging in PWS, independent of GH. Longitudinal research is needed to determine the influence of LTL on aging in PWS.

Indexed as

AdolescentAdultAging, PrematureCase-Control StudiesCross-Sectional StudiesFemaleFollow-Up StudiesHumansIncidenceMaleNetherlandsPrader-Willi SyndromePrognosisTelomereYoung Adultgrowth hormonePrader–Willi syndrometelomere length

Identifiers

PMID31689713
PMCPMC7150612
OpenAlexW2985225008

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.