Evidence map›Paper›PMID 31689374›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

PRADC1: a novel metabolic-responsive secretory protein that modulates physical activity and adiposity.

Susana Rodriguez, Ashley N Stewart, Xia Lei, Xi Cao, Hannah C Little, Vincent Fong, Dylan C Sarver, G William Wong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding.American journal of physiology. Endocrinology and metabolism · 2022
    Article
  3. CTRP11 contributes modestly to systemic metabolism and energy balance.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Susana RodriguezDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ashley N StewartDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Xia LeiDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Xi CaoDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Hannah C LittleDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Vincent FongDepartment of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Dylan C SarverDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
G William WongDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
CTRP and Metabolic ControlR01DK084171 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Guang William Wong · 2010 to 2026
$8.0M
NIDDK NIH HHS R01 DK084171NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Interorgan communication mediated by secreted proteins plays a pivotal role in metabolic homeostasis, yet the function of many circulating secretory proteins remains unknown. Here, we describe the function of protease-associated domain-containing 1 (PRADC1), an enigmatic secretory protein widely expressed in humans and mice. In metabolically active tissues (liver, muscle, fat, heart, and kidney), we showed that

Indexed as

AdiposityLipid MetabolismMovementAdipose TissueAnimalsFemaleGlucoseIntercellular Signaling Peptides and ProteinsKidneyLiverMaleMiceMice, Inbred C57BLMyocardiumGlucoseIntercellular Signaling Peptides and ProteinsPradc1 protein, mousediabetesinsulin resistancelipid metabolismobesity

Identifiers

PMID31689374
PMCPMC6894076
OpenAlexW2988288782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.