ArticlePloS one2019
Average and time-specific maternal prenatal inflammatory biomarkers and the risk of labor epidural associated fever.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Epidural analgesia supplemented with lidocaine reduces maternal fever during labor: a randomized controlled trial.Frontiers in pharmacology · 2026Trial
- Sensory Block Height and Risk of Maternal Fever in Epidural Labour Analgesia: A Prospective Cohort Study.Journal of pain research · 2026Article
- Effects of Dexmedetomidine or Sufentanil Plus Low-Dose Ropivacaine for Epidural Labor Analgesia on Maternal Intrapartum Temperature Changes and Delivery Outcomes.Journal of pain research · 2026Article
- Low lymphocyte-to-monocyte ratio and accelerated temperature rise in epidural-related maternal fever: a prospective cohort study.BMC anesthesiology · 2025Article
- Machine learning algorithms to predict epidural-related maternal fever: a retrospective study.Frontiers in pharmacology · 2025Article
- Machine Learning-Driven Intrapartum Fever Prediction: A Comprehensive Large Retrospective Cohort Study Integrating Inflammatory and Obstetric Markers.International journal of general medicine · 2025Article
- Intrapartum fever complicated with maternal bacteremia: prevalence, bacteriology, and risk factors.Archives of gynecology and obstetrics · 2024Article
- Nomogram for perinatal prediction of intrapartum fever: a retrospective case-control study.BMC pregnancy and childbirth · 2021Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe use of labor epidural analgesia has been associated with intrapartum fever, known as labor epidural associated fever (LEAF). LEAF is most commonly non-infectious in origin and associated with elevated inflammatory cytokines.
methodsThe LIFECODES pregnancy cohort was designed to prospectively collect data to evaluate the association of maternal inflammatory biomarkers with preterm birth in women who delivered between 2007 and 2008 at Brigham and Women's Hospital. Our secondary analysis of the data from the cohort identified 182 women for whom inflammatory biomarkers (i.e. interleukin-10, interleukin-1β, interleukin-6, tumor necrosis factor-α and C-reactive protein) collected longitudinally over four prenatal visits was available. Maternal temperature and other clinical variables were abstracted from medical records. The primary outcome, the presence of LEAF, was defined as oral temperature ≥ 38°C (≥100.4°F) after epidural analgesia initiation. Multivariable logistic regression estimated the association between inflammatory biomarker concentrations and the odds of developing an intrapartum fever after adjusting for a number of potential confounders.
resultsWomen who developed LEAF were more likely to have a longer duration of epidural analgesia, whereas women who did not develop LEAF were more likely to have induced labor and positive or unknown Group B Streptococcus colonization status. However, no differences were seen by nulliparity, mode of delivery, white blood cell count at admission, baseline temperature, length of rupture of membranes and number of cervical exams performed during labor. Unadjusted and multivariable logistic regression models did not provide evidence for or exclude an association between individual maternal inflammatory biomarkers and the odds of developing LEAF, regardless of visit time-period.
conclusionThe predictive value of maternal inflammatory biomarkers measured during early- and mid-pregnancy for the risk of developing LEAF cannot be excluded.
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