ArticleJournal of the American Chemical Society2019
Synthesis of Benzylic Alcohols by C-H Oxidation.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- A Bis(arenesulfonyl) Peroxide, an Ambient-Stable Oxidant, Is a Strong p‑Dopant for Organic Semiconductors.Chemistry of materials : a publication of the American Chemical Society · 2026Article
- Electrochemical Direct Benzylic C-H Hydroxylation with HCommunications chemistry · 2026Article
- Nickel-catalyzed hydroxymethylation with α-siliconChemical science · 2026Article
- Single-iron catalyst with heterogenized TEMPO for selective toluene electrooxidation to benzaldehyde at low potentials.Nature communications · 2026Article
- Structure-based modeling reveals molecular basis for CYP153A6's novel activity toward toluene derivatives.Scientific reports · 2026Article
- Selective Toluene Electrooxidation to Benzyl Alcohol.Journal of the American Chemical Society · 2025Article
- Photocatalytic Synthesis of Substituted 2-Aryl Morpholines via Diastereoselective Annulation.Journal of the American Chemical Society · 2025Article
- Aerobic oxidation of alkylarenes and polystyrene waste to benzoic acidsChemical science · 2025Article
- C(spACS catalysis · 2025Article
- Na-Promoted Bimetallic Hydroxide Nanoparticles for Aerobic C-H Activation: Catalyst Design Principles and Insights into Reaction Mechanism.ACS applied materials & interfaces · 2024Article
- Total synthesis of naturally occurring abietane diterpenoidsRSC advances · 2024Article
- The untold story of starch as a catalyst for organic reactions.RSC advances · 2024Review
- Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing.Acta pharmaceutica Sinica. B · 2024Review
- Copper-Catalyzed Benzylic C-H Cross-Coupling Enabled by Redox Buffers: Expanding Synthetic Access to Three-Dimensional Chemical Space.Accounts of chemical research · 2023Article
- Cu(ii)-mediated direct intramolecular cyclopropanation of distal olefinic acetate: access to cyclopropane-fused γ-lactones.Chemical science · 2023Article
- Benzylic C-H Esterification with Limiting C-H Substrate Enabled by Photochemical Redox Buffering of the Cu Catalyst.Journal of the American Chemical Society · 2023Article
- Synthesis of triarylmethanes by silyl radical-mediated cross-coupling of aryl fluorides and arylmethanes.Chemical science · 2023Article
- Anaerobic Hydroxylation of C(spJournal of the American Chemical Society · 2023Article
- Sequential Iron-Catalyzed C(spMolecules (Basel, Switzerland) · 2022Article
- Electrochemical aromatic C-H hydroxylation in continuous flow.Nature communications · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective methylene C-H oxidation for the synthesis of alcohols with a broad scope and functional group tolerance is challenging due to the high proclivity for further oxidation of alcohols to ketones. Here, we report the selective synthesis of benzylic alcohols employing bis(methanesulfonyl) peroxide as an oxidant. We attempt to provide a rationale for the selectivity for monooxygenation, which is distinct from previous work; a proton-coupled electron transfer mechanism (PCET) may account for the difference in reactivity. We envision that our method will be useful for applications in the discovery of drugs and agrochemicals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.