Evidence map›Paper›PMID 31688971›Full record

ArticleAlcoholism, clinical and experimental research2019

Fetal Alcohol Spectrum Disorders in a Pacific Southwest City: Maternal and Child Characteristics.

Christina D Chambers, Claire Coles, Julie Kable, Natacha Akshoomoff, Ronghui Xu, Jennifer A Zellner, Gordon Honerkamp-Smith, Melanie A Manning, Margaret P Adam, Kenneth Lyons Jones

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcoholism, clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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  18. Screening for Alcohol Use in Pregnancy: a Review of Current Practices and Perspectives.International journal of mental health and addiction · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Christina D ChambersDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California.ORCID 0000-0003-4675-7722
Claire ColesDepartment of Psychiatry, School of Medicine, Emory University, Atlanta, Georgia.ORCID 0000-0003-3399-6644
Julie KableDepartment of Psychiatry, School of Medicine, Emory University, Atlanta, Georgia.
Natacha AkshoomoffDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California San Diego, La Jolla, California.
Ronghui XuDepartment of Family Medicine and Public Health, School of Medicine, University of California San Diego, La Jolla, California.
Jennifer A ZellnerDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California.
Gordon Honerkamp-SmithDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California.
Melanie A ManningDepartments of Pathology and Pediatrics, Stanford University School of Medicine, Stanford, California.
Margaret P AdamDepartment of Pediatrics, School of Medicine, University of Washington, Seattle, Washington.
Kenneth Lyons JonesDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California.
University of California San Diego · USEmory University · USStanford Medicine · USUniversity of Washington · US

Funding

Collaboration to Establish the Prevalence of FASD in San Diego, CAU01AA019879 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHAMBERS, CHRISTINA · 2010 to 2017
$9.2M
NIAAA NIH HHS U01 AA019879
6 · The paper itself

Abstract

backgroundThere are limited data on the characteristics of children with fetal alcohol spectrum disorders (FASD) and their mothers from the general population in the United States.

methodsDuring the 2012 and 2013 academic years, first-grade children in a large urban Pacific Southwest city were invited to participate in a study to estimate the prevalence of FASD. Children who screened positive on weight, height, or head circumference ≤25th centile or on parental report of developmental concerns were selected for evaluation, along with a random sample of those who screened negative. These children were examined for dysmorphology and neurobehavior and their mothers or collateral sources were interviewed. Children were classified as fetal alcohol syndrome (FAS), partial fetal alcohol syndrome (pFAS), alcohol-related neurodevelopmental disorder (ARND), or No FASD.

resultsA total of 854 children were evaluated; 5 FAS, 44 pFAS, 44 ARND, and 761 No FASD. Children with FAS or pFAS were more likely to have dysmorphic features, and 32/49 (65.3%) of those met criteria for neurobehavioral impairment on cognitive measures with or without behavioral deficits. In contrast, 28/44 (63.6%) of children with ARND met criteria on behavioral measures alone. Mothers of FASD children were more likely to recognize pregnancy later, be unmarried, and report other substance use or psychiatric disorders, but did not differ on age, socioeconomic status, education, or parity. Mothers of FASD children reported more drinks/drinking day each trimester. The risk of FASD was elevated with increasing number of drinks/drinking day prior to pregnancy recognition, even at the level of 1 drink per day (adjusted odds ratio 3.802, 95% confidence interval 1.634, 8.374).

conclusionsData from this general population sample in a large urban region in the United States demonstrate the variability of expression of FASD and point to risk and protective factors for mothers in this setting.

Indexed as

AdultCase-Control StudiesChildCitiesFemaleFetal Alcohol Spectrum DisordersHumansMaleMothersRisk FactorsSouthwestern United StatesYoung AdultFetal Alcohol Spectrum DisordersPregnant WomenPrenatal Alcohol UsePrevalence

Identifiers

PMID31688971
PMCPMC6904497
OpenAlexW2983313913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.