ArticleJournal of public health management and practice : JPHMP
Factors Associated With Latent Tuberculosis Infection Treatment Failure Among Patients With Commercial Health Insurance-United States, 2005-2016.
Article in Journal of public health management and practice : JPHMP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Challenges in implementing preventive treatment for latent tuberculosis infection: a narrative review from provider and demand-side perspectives.Frontiers in public health · 2025Pooled it
- Factors Associated With Discontinuation of Tuberculosis Preventive Treatment: Post Hoc Analysis of 2 Randomized, Controlled Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Trial
- Low treatment completion rates reveal gaps in the LTBI care cascade among university students.Frontiers in tuberculosis · 2025Article
- Case Report: Disseminated Tuberculosis After Kidney Transplantation.The American journal of tropical medicine and hygiene · 2024Article
- Latent tuberculosis infection treatment completion in Biscay: differences between regimens and monitoring approaches.Frontiers in medicine · 2023Article
- A narrative review of tuberculosis in the United States among persons aged 65 years and older.Journal of clinical tuberculosis and other mycobacterial diseases · 2022Review
- Diagnostic code agreement for electronic health records and claims data for tuberculosis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2020Article
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6 authors.
Funding
Abstract
contextApproximately 80% of US tuberculosis (TB) cases verified during 2015-2016 were attributed to untreated latent TB infection (LTBI). Identifying factors associated with LTBI treatment failure might improve treatment effectiveness.
objectiveTo identify patients with indicators of isoniazid (INH) LTBI treatment initiation, completion, and failure.
methodsWe searched inpatient and outpatient claims for International Classification of Diseases (Ninth and Tenth Revisions), National Drug, and Current Procedural Terminology codes. We defined treatment completion as 180 days or more of INH therapy during a 9-month period. We defined LTBI treatment failure as an active TB disease diagnosis more than 1 year after starting LTBI treatment among completers and used exact logistic regression to model possible differences between groups. Among treatment completers, we matched 1 patient who failed treatment with 2 control subjects and fit regression models with covariates documented on medical claims paid 6 months or less before INH treatment initiation.
participantsCommercially insured US patients in a large commercial database with insurance claims paid during 2005-2016.
main outcome measures(1) Trends in treatment completion; (2) odds ratios (ORs) for factors associated with treatment completion and treatment failure.
resultsOf 21 510 persons who began LTBI therapy during 2005-2016, 10 725 (49.9%) completed therapy. Treatment noncompletion is associated with those younger than 45 years, living in the Northeast or South Census regions, and women. Among persons who completed treatment, 30 (0.3%) progressed to TB disease. Diagnoses of rheumatoid arthritis during the 6 months before treatment initiation and being aged 65 years or older (reference: ages 0-24 years) were significantly associated with INH LTBI treatment failure (adjusted exact OR = 5.1; 95% CI, 1.2-28.2; and adjusted exact OR = 5.1; 95% CI, 1.2-25.3, respectively).
conclusionApproximately 50% of persons completed INH LTBI therapy, and of those, treatment failure was associated with rheumatoid arthritis and persons 65 years or older among a cohort of US LTBI patients with commercial health insurance.
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