ArticlePsychosomatic medicine
The Association of Comorbid Depression and Anxiety Symptoms With Disability Onset in Older Adults.
Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Prevalence of depressive and anxiety symptoms among Chinese older adults during the COVID-19 pandemic: A systematic review and meta-analysis.Journal of geriatric psychiatry and neurology · 2022Pooled it
- tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT).Brain stimulationTrial
- Engagement and Outcomes Associated With Message-Based Psychotherapy Among Older and Younger Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Heterogeneous and nonlinear associations between depressive symptoms and functional disability in older Chinese adults.BMC psychology · 2026Article
- Nitrous oxide for late-life depression with inadequate antidepressant response: a randomised controlled trial.EClinicalMedicine · 2026Article
- Quality of life analysis in community pharmacy using deep learning and explainability methods.JAMIA open · 2026Article
- Investigating biotypes and neural characteristics among anxiety, depression, and comorbidity via a novel noisy label learning method.Psychoradiology · 2026Article
- A bibliometric analysis of the intersection of circadian rhythm, anxiety disorders, aging, and comorbidity.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Gender differences in symptom profiles of individuals being treated for mood disorders.Journal of mood and anxiety disorders · 2025Article
- Rejuvenation alleviates prolonged postsurgical pain in aging mice by mitigating inflammaging.Pain · 2025Article
- Predictors of mood disturbance in older adults: a longitudinal cohort study.European geriatric medicine · 2025Article
- Frailty in older adults: A systematic review of risk factors and early intervention pathways.Intractable & rare diseases research · 2025Review
- Construction of disability risk prediction model for the elderly based on machine learning.Scientific reports · 2025Article
- Identifying comorbidity patterns of mental health disorders in community-dwelling older adults: a cluster analysis.BMC geriatrics · 2025Article
- Article
- Predictive features analysis and nomogram construction for predicting depression in elderly patients.Frontiers in psychology · 2025Article
- Investigation on the Anxiety and Depression Status of Thalassemia Carriers After Genetic Counseling.Neuropsychiatric disease and treatment · 2025Article
- Increased Depressive and Anxiety Symptoms Predict Increased Severity of Functional Impairment After Five Years: A Nationally Representative Retrospective Cohort Study.Journal of patient-centered research and reviews · 2025Article
- Prevalence and factors affecting anxiety and depression among adult people with physical disabilities in Saudi Arabia: a cross-sectional study.Frontiers in psychology · 2025Article
- Psychological distress and mental health diagnoses in adults by disability and functional difficulty status: Findings from the 2021 national health interview survey.Disability and health journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveDespite the high prevalence of late-life depression and anxiety at threshold and subthreshold levels, their joint role in the disablement process remains unclear. This study aims to examine the association of comorbid occurring depression and anxiety across the full spectrum of symptom severity with disability onset in older adults.
methodsThe study included 3663 participants from the 2011 National Health and Aging Trends Study, who reported no limitations in self-care and mobility activities at baseline. Disability onset was defined as a report of receiving help from another person in any of the activities for 3 consecutive months. Depression and anxiety symptoms were measured using the four-item Patient Health Questionnaire, grouped into low, mild, and moderate/severe symptom groups. Cox proportional hazards models were used to estimate relative risks for disability onset over a 5-year period by depression/anxiety symptom groups.
resultsA total of 1047 participants developed disability (24.6%; 6.0 per 1000 person-months). At baseline, one-fifth of the sample reported symptoms that were mild (n = 579 [14.9%]; 31.6% with disability onset) or moderate/severe (n = 156 [4.2%]; 38.1% with disability onset). After adjustment for sociodemographics, there was a dose-response relationship between depression/anxiety symptom groups and disability onset (mild versus low: hazard ratio [HR] = 1.43, 95% confidence interval [CI] = 1.20-1.70; moderate/severe versus low: HR = 1.94, 95% CI = 1.45-2.59). The increased risk remained significant after adjustment for health status variables for the mild symptom group (HR = 1.26, 95% CI = 1.07-1.49), but not for the moderate/severe symptom group (HR = 1.30, 95% CI = 0.94-1.79), possibly reflecting lower statistical power.
conclusionsFindings suggest that the full spectrum of depression and anxiety symptoms are associated with increased risk for disability in late life. Their role in the disablement process warrants further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.