Evidence map›Paper›PMID 31688597›Full record

ArticlePancreas

Portal Vein Thrombosis After Total Pancreatectomy and Islet Autotransplant: Prophylaxis and Graft Impact.

Alexandria J Robbins, Mariya E Skube, Melena D Bellin, Ty B Dunn, Scott A Chapman, K Louise Berry, Elizabeth Lusczek, Gregory J Beilman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pancreas. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Observational
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Alexandria J RobbinsFrom the Departments of Surgery.
Mariya E SkubeFrom the Departments of Surgery.
Melena D BellinMedicine.
Ty B DunnDepartment of Surgery, University of Pennsylvania, Philadelphia, PA.
Scott A ChapmanDepartment of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN.
K Louise BerryFrom the Departments of Surgery.
Elizabeth LusczekFrom the Departments of Surgery.
Gregory J BeilmanFrom the Departments of Surgery.
University of Minnesota · USUniversity of Minnesota Medical Center · USUniversity of Pennsylvania · US

Funding

Training the Next Generation of Surgeon-Scientists in PancreatologyT32DK108733 · NIDDK · UNIVERSITY OF MINNESOTA · PI Srinath Chinnakotla, MASATO YAMAMOTO · 2017 to 2026
$1.4M
NIDDK NIH HHS T32 DK108733
6 · The paper itself

Abstract

objectivesTo determine the rate of portal vein thrombosis (PVT) based on pharmacologic prophylaxis protocol and the impact of PVT on islet graft function after total pancreatectomy with islet autotransplantation (TPIAT).

methodsWe compared the incidence of PVT, postsurgical bleeding, and thrombotic complications in patients undergoing TPIAT between 2001 and 2018 at the University of Minnesota who received either unfractionated heparin (UFH) or enoxaparin for postoperative PVT prophylaxis. Six-month and 1-year graft function was compared between patients who developed PVT and those who did not.

resultsTwelve patients (6.6%) developed a PVT, which resolved by 6 months after TPIAT in 10 patients. There was no statistically significant difference in PVT rate between patients who received UFH or enoxaparin for prophylaxis (P = 0.54). Patients who received enoxaparin developed other thrombotic complications more often (6% vs 0%, P = 0.02). Islet graft function did not differ in patients who developed PVT versus those who did not.

conclusionsThere was no difference between enoxaparin or UFH prophylaxis in preventing PVT, but there may be a higher incidence of other thrombotic complications with enoxaparin. In the setting of routine screening and anticoagulation therapy, PVT is a self-limited process.

Indexed as

Portal VeinAdultEnoxaparinFemaleHeparinHumansIslets of Langerhans TransplantationMaleMiddle AgedPancreatectomyPostoperative ComplicationsRetrospective StudiesTransplantation, AutologousVenous ThrombosisEnoxaparinHeparin

Identifiers

PMID31688597
PMCPMC7181460
OpenAlexW2985774233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.