Evidence map›Paper›PMID 31688587›Full record

ArticlePancreas

Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Mark E Lowe, Dana K Andersen, Richard M Caprioli, Jyoti Choudhary, Zobeida Cruz-Monserrate, Anil K Dasyam, Christopher E Forsmark, Fred S Gorelick, Joe W Gray, Mark Haupt and 12 more

Open access · greenAbstract read
In one paragraph

Article in Pancreas. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Biomarkers of Chronic Pancreatitis: A systematic literature review.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2021
    Pooled it
  2. Personalizing treatment of pancreatitis-associated chronic pain: the need for an integrated omics approach.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 18 institutions in 2 countries.

Mark E LoweFrom the Department of Pediatrics, School of Medicine, Washington University, St Louis, MO.
Dana K AndersenThe Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Richard M CaprioliDepartments of Biochemistry.
Jyoti ChoudharyInstitute of Cancer Research, London, United Kingdom.
Zobeida Cruz-MonserrateDivision of Gastroenterology, Hepatology, and Nutrition, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH.
Anil K DasyamDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA.
Christopher E ForsmarkThe Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, FL.
Fred S GorelickDepartments of Internal Medicine.
Joe W GrayKnight Cancer Institute, Oregon Health and Science University, Portland, OR.
Mark HauptAriel Precision Medicine, Pittsburgh, PA.
Kimberly A KellyDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.
Kenneth P OliveDepartment of Medicine.
Sylvia K PlevritisDepartments of Biomedical Data Science.
Noa RappaportInstitute for Systems Biology, Seattle, WA.
Holger R RothDeep Learning for Medical Imaging, NVIDIA Corporation, Bethesda, MD.
Hanno SteenProteomics Center, Boston Children's Hospital, Department of Pathology, Harvard Medical School, Boston, MA.
S Joshua SwamidassDepartment of Pathology and Immunology, School of Medicine, Washington University, St Louis, MO.
Temel TirkesDepartment of Radiology and Imaging Sciences, School of Medicine, Indiana University, Indianapolis, IN.
Aliye UcDivision of Gastroenterology, Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA.
Kirill VeselkovComputational Medicine and Systems Medicine, Department of Digestion, Metabolism and Reproduction, Imperial College, London, United Kingdom.
David C WhitcombDepartments of Medicine.
Aida HabtezionDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA.
Stanford University · USUniversity of Pittsburgh · USWashington University in St. Louis · USColumbia University Irving Medical Center · USHarvard University · USImperial College London · GBIndiana University – Purdue University Indianapolis · USInstitute for Systems Biology · USInstitute of Cancer Research · GBNational Institute of Diabetes and Digestive and Kidney Diseases · USNvidia (United States) · USOregon Health & Science University · USThe Ohio State University Wexner Medical Center · USUniversity of Florida · USUniversity of Iowa · USUniversity of Virginia · USVA Connecticut Healthcare System · USVanderbilt University · US

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
Year 9 Administrative Supplement to INSPPIRE 2U01DK108334 · NIDDK · UNIVERSITY OF IOWA · PI MARK E. LOWE, Aliye Uc · 2015 to 2026
$10.5M
Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research NetworkU01DK108323 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Jeffrey James Easler, Evan L Fogel · 2015 to 2026
$6.5M
UPMC Clinical Center for the Study of Chronic Pancreatitis and DiabetesU01DK108306 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Frederico G. S. Toledo, Dhiraj Yadav · 2015 to 2026
$6.4M
The Stanford Clinical Center for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic CancerU01DK108300 · NIDDK · STANFORD UNIVERSITY · PI Sohail Z Husain, Walter Gwang-Up Park · 2015 to 2026
$6.3M
The Ohio State University Pancreatic Disorders Network (OSU-PDN)U01DK108327 · NIDDK · OHIO STATE UNIVERSITY · PI CONWELL, DARWIN LEWIS, HART, PHILIP A. · 2015 to 2024
$5.5M
Role of Lipocalin 2 in Pancreatic CancerR01CA223204 · NCI · OHIO STATE UNIVERSITY · PI CRUZ-MONSERRATE, ZOBEIDA · 2018 to 2022
$1.9M
NIDDK NIH HHS P30 DK054759NIDDK NIH HHS U01 DK108300NIDDK NIH HHS U01 DK108306NIDDK NIH HHS U01 DK108323NIDDK NIH HHS U01 DK108334Wellcome Trust
6 · The paper itself

Abstract

A workshop on research gaps and opportunities for Precision Medicine in Pancreatic Disease was sponsored by the National Institute of Diabetes and Digestive Kidney Diseases on July 24, 2019, in Pittsburgh. The workshop included an overview lecture on precision medicine in cancer and 4 sessions: (1) general considerations for the application of bioinformatics and artificial intelligence; (2) omics, the combination of risk factors and biomarkers; (3) precision imaging; and (4) gaps, barriers, and needs to move from precision to personalized medicine for pancreatic disease. Current precision medicine approaches and tools were reviewed, and participants identified knowledge gaps and research needs that hinder bringing precision medicine to pancreatic diseases. Most critical were (a) multicenter efforts to collect large-scale patient data sets from multiple data streams in the context of environmental and social factors; (b) new information systems that can collect, annotate, and quantify data to inform disease mechanisms; (c) novel prospective clinical trial designs to test and improve therapies; and (d) a framework for measuring and assessing the value of proposed approaches to the health care system. With these advances, precision medicine can identify patients early in the course of their pancreatic disease and prevent progression to chronic or fatal illness.

Indexed as

Biomedical ResearchPancreatic DiseasesPrecision MedicineBiomarkersComputational BiologyDatasets as TopicDeep LearningHumansMetabolomicsResearchBiomarkers

Identifiers

PMID31688587
PMCPMC7282491
OpenAlexW2983482125

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.