ReviewJournal of glaucoma2019
Does Retinal Ganglion Cell Loss Precede Visual Field Loss in Glaucoma?
Review in Journal of glaucoma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Optical coherence tomography angiography of the macular retina and choroid in glaucoma: a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Smaller spot sizes show bitemporal visual field defects missed by standard Humphrey perimetry.American journal of ophthalmology case reports · 2025Article
- Premacular membranes and glaucoma: a review of clinical and therapeutic considerations.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- Effects of Anatomical Variation on Ganglion Cell and Nerve Fibre Layer Evaluation by Optical Coherence Tomography.Journal of clinical medicine · 2024Article
- Retinal Ganglion Cell Content Underlying Standard Automated Perimetry Size I to V Visual Sensitivities in the Non-Human Primate Experimental Glaucoma Model.Investigative ophthalmology & visual science · 2024Article
- Characterization of neural damage and neuroinflammation in Pax6 small-eye mice.Experimental eye research · 2024Article
- Evaluating the performance of OCT in assessing static and potential dynamic properties of the retinal ganglion cells and nerve fiber bundles in the living mouse eye.Biomedical optics express · 2023Article
- Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma.Cellular reprogramming · 2023Article
- Structure-function relationship between magnetic resonance imaging lesion areas and visual field defects in initial optic neuritis with altitudinal hemianopsia.Japanese journal of ophthalmology · 2023Article
- Comparing retinal sensitivities on blue-on-yellow and green-on-yellow perimetry in glaucoma suspects.Indian journal of ophthalmology · 2022Article
- Article
- Long-term retinal protection by MEK inhibition in Pax6 haploinsufficiency mice.Experimental eye research · 2022Article
- Electrical neurostimulation in glaucoma with progressive vision loss.Bioelectronic medicine · 2022Article
- Relationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknesses.Translational vision science & technology · 2021Article
- Quantification of Retinal Ganglion Cell Morphology in Human Glaucomatous Eyes.Investigative ophthalmology & visual science · 2021Article
- Slowed Saccadic Reaction Times in Seemingly Normal Parts of Glaucomatous Visual Fields.Frontiers in medicine · 2021Article
- Time Lag Between Functional Change and Loss of Retinal Nerve Fiber Layer in Glaucoma.Investigative ophthalmology & visual science · 2020Article
- A Topographic Comparison of OCT Minimum Rim Width (BMO-MRW) and Circumpapillary Retinal Nerve Fiber Layer (cRNFL) Thickness Measures in Eyes With or Suspected Glaucoma.Journal of glaucoma · 2020Article
- Improving the Detection of Glaucoma and Its Progression: A Topographical Approach.Journal of glaucoma · 2020Article
- The Discriminatory Ability of Ganglion Cell Inner Plexiform Layer Complex Thickness in Patients with Preperimetric Glaucoma.Journal of current ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
It is often said that substantial retinal ganglion cells are lost before glaucomatous damage is detected by standard automated perimetry. There are 4 key articles referenced to support this belief. To test the hypothesis that the 4 key articles are incorrectly cited, the publications in the first 6 months of 2019 that reference 1 or more of these 4 articles were examined. In particular, the degree to which the quotes from these 2019 publications accurately reflected the evidence in the 4 key articles was assessed. These quotes are inadequately supported by the data, and in some cases even by the conclusions found in the abstracts of the key articles. This is despite several review articles that have questioned the evidence in these key articles. Further, a case can be made that the evidence in the key articles better supports the opposite conclusion. That is, the data suggest that sensitivity loss can be seen on standard automated perimetry before retinal ganglion cells are missing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.