Evidence map›Paper›PMID 31687931›Full record

ArticleeLife2019

RNA from a simple-tandem repeat is required for sperm maturation and male fertility in

Wilbur Kyle Mills, Yuh Chwen G Lee, Antje M Kochendoerfer, Elaine M Dunleavy, Gary H Karpen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 70 citations in OpenAlex.

  1. Satellite DNAs in Drosophila koepferae (repleta group) reveal patterns of origin, chromosomal organization, transcription, and turnover in the buzzatii cluster.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
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  9. Cytoplasmic incompatibility factor proteins fromProceedings. Biological sciences · 2025
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  17. Derepression of Y-linked multicopy protamine-like genes interferes with sperm nuclear compaction inProceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Wilbur Kyle MillsDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-4842-4190
Yuh Chwen G LeeDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-0081-7892
Antje M KochendoerferCentre for Chromosome Biology, National University of Ireland, Galway, Ireland.ORCID 0000-0001-5862-667X
Elaine M DunleavyCentre for Chromosome Biology, National University of Ireland, Galway, Ireland.ORCID 0000-0001-6885-0421
Gary H KarpenDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0003-1534-0385
Lawrence Berkeley National Laboratory · USOllscoil na Gaillimhe – University of Galway · IEUniversity of California, Berkeley · US

Funding

Organization and Function of the Heterochromatin Holodomain and SubdomainsR01GM117420 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KARPEN, GARY H · 2016 to 2019
$2.5M
Regulation of Centromere Protein Stability and Impact on Cancer ProgressionR01GM119011 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KARPEN, GARY H · 2016 to 2019
$2.1M
Functional and evolutionary consequences of the epigenetic effects of transposable elementsK99GM121868 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI LEE, GRACE YUH CHWEN · 2017 to 2018
$180k
National Science Foundation Graduate Research FellowshipNIGMS NIH HHS R01 GM117420NIGMS NIH HHS R01 GM119011NIH HHS K99 GM121868NIH HHS RO1 GM117420Science Foundation Ireland-Health Research Board-Wellcome Trust (SFI-HRB-WT) 00105/Z/12/ZScience Foundation Ireland - President of Ireland Young Research Award (SFI-PIYRA) 13/YI/2187
6 · The paper itself

Abstract

Tandemly-repeated DNAs, or satellites, are enriched in heterochromatic regions of eukaryotic genomes and contribute to nuclear structure and function. Some satellites are transcribed, but we lack direct evidence that specific satellite RNAs are required for normal organismal functions. Here, we show satellite RNAs derived from AAGAG tandem repeats are transcribed in many cells throughout

Indexed as

Gene Expression Regulation, DevelopmentalMicrosatellite RepeatsAnimalsDrosophila melanogasterEmbryo, NonmammalianEvolution, MolecularFertilityHeterochromatinHistonesMaleProtaminesRNA, MessengerSpermatocytesSpermatogenesisSperm MaturationTranscription, GeneticHeterochromatinHistonesProtaminesRNA, Messengercell biologychromosomesD. melanogastergene expressionheterochromatinhistone-protamine exchangenon-coding RNArepetitive RNAsatellite RNAspermatogenesis

Identifiers

PMID31687931
PMCPMC6879302
OpenAlexW2987753035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.