Evidence map›Paper›PMID 31687859›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

Design, synthesis,

Ashok Aspatwar, Nanda Kumar Parvathaneni, Harlan Barker, Emilie Anduran, Claudiu T Supuran, Ludwig Dubois, Philippe Lambin, Seppo Parkkila, Jean-Yves Winum

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Aryl derivatives of 3Journal of enzyme inhibition and medicinal chemistry · 2023
    Article
  3. Synthesis, biological evaluation and theoretical studies of (Journal of enzyme inhibition and medicinal chemistry · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. The Versatility in the Applications of Dithiocarbamates.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Ashok AspatwarFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0002-6938-7835
Nanda Kumar ParvathaneniDepartment of Precision Medicine, The M-Lab, GROW - School for Oncology and Developmental Biology, Maastricht Comprehensive Cancer Centre, Maastricht University Medical Centre, Maastricht, The Netherlands.
Harlan BarkerFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Emilie AnduranDepartment of Precision Medicine, The M-Lab, GROW - School for Oncology and Developmental Biology, Maastricht Comprehensive Cancer Centre, Maastricht University Medical Centre, Maastricht, The Netherlands.
Claudiu T SupuranNEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze, Italy.ORCID http://orcid.org/0000-0003-4262-0323
Ludwig DuboisDepartment of Precision Medicine, The M-Lab, GROW - School for Oncology and Developmental Biology, Maastricht Comprehensive Cancer Centre, Maastricht University Medical Centre, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-8887-4137
Philippe LambinDepartment of Precision Medicine, The M-Lab, GROW - School for Oncology and Developmental Biology, Maastricht Comprehensive Cancer Centre, Maastricht University Medical Centre, Maastricht, The Netherlands.
Seppo ParkkilaFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0001-7323-8536
Jean-Yves WinumInstitut des Biomolécules, Max Mousseron (IBMM) UMR 5247 CNRS, ENSCM, Université de Montpellier, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Montpellier, Montpellier, France.ORCID http://orcid.org/0000-0003-3197-3414
École Nationale Supérieure de Chimie de Montpellier · FRTampere University · FIMaastricht University Medical Centre · NLUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the aim to obtain novel compounds possessing both strong affinity against human carbonic anhydrases and low toxicity, we synthesised novel thiourea and sulphonamide derivatives

Indexed as

AnimalsCarbonic Anhydrase ICarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarbonic Anhydrase IVCarrier ProteinsDose-Response Relationship, DrugHumansLarvaMolecular StructureNerve Tissue ProteinsNitroimidazolesStructure-Activity RelationshipZebrafish4-nitroimidazoleCA2 protein, humanCA4 protein, humanCarbonic Anhydrase ICarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarbonic Anhydrase IVCarrier ProteinsNerve Tissue ProteinsNitroimidazolescarbonic anhydrase inhibitorsCarbonic anhydraseslethal concentrationsynthesistoxicity evaluationzebrafish embryos

Identifiers

PMID31687859
PMCPMC6844379
OpenAlexW2986637157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.