Evidence map›Paper›PMID 31687570›Full record

ArticleHeliyon2019

Acute effects of methcathinone and manganese in mice: A dose response study.

Andres Asser, Sulev Kõks, Ursel Soomets, Anton Terasmaa, Martin Sauk, Mall Eltermaa, Piret Piip, Kumari Ubhayasekera, Jonas Bergquist, Pille Taba

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Andres AsserDepartment of Neurology and Neurosurgery, University of Tartu, Puusepa 8, Tartu, 51014, Estonia.
Sulev KõksPerron Institute for Neurological and Translational Science, University of Western Australia, Perth, WA, Australia.
Ursel SoometsDepartment of Biochemistry, University of Tartu, Ravila 19, Tartu, 50411, Estonia.
Anton TerasmaaDepartment of Physiology, University of Tartu, Ravila 19, Tartu, 50411, Estonia.
Martin SaukInstitute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu, 51010, Estonia.
Mall EltermaaInstitute of Biomedicine and Translational Medicine, University of Tartu, Ravila 19, Tartu, 50411, Estonia.
Piret PiipDepartment of Neurology and Neurosurgery, University of Tartu, Puusepa 8, Tartu, 51014, Estonia.
Kumari UbhayasekeraDepartment of Chemistry, Biomedical Center, Uppsala University, SE-751 24, Uppsala, Sweden.
Jonas BergquistDepartment of Chemistry, Biomedical Center, Uppsala University, SE-751 24, Uppsala, Sweden.
Pille TabaDepartment of Neurology and Neurosurgery, University of Tartu, Puusepa 8, Tartu, 51014, Estonia.
University of Tartu · EEUppsala University · SEThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An intravenously injectable illicit drug made by mixing pseudoephedrine, potassium permanganate, vinegar and water, yielding methcathinone (Mcat) and manganese (Mn), induces an extrapyramidal syndrome with parkinsonism, dystonia, gait and balance disorders similar to manganism. Although the cause of the syndrome is largely attributed to Mn, the interaction of the drug's individual components is not known and the role of Mcat is possibly underestimated. Aim of the present study was to analyze dose-dependent behavioral effects of the mixture and its two main active components Mcat and Mn in an acute setting and determine the lethal doses of each substance. Three groups of C57BL/6 mice were injected intraperitoneally with (1) the drug mixture containing 10, 25, 50, 100 or 150 mg of Mcat and respectively 1.6, 3.8, 6.9, 17.1 and 22.6 mg of Mn per kilogram of body weight; (2) 10, 25, 50, 100, 150, 200 or 300 mg of racemic Mcat/kg of body weight; (3) MnCl

Indexed as

Behavioral neuroscienceDose-response relationshipEphedroneManganeseMethcathinoneNervous systemNeuroscienceNeurotoxicologyToxicologyToxic parkinsonism

Identifiers

PMID31687570
PMCPMC6819833
OpenAlexW2973649162

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.