Evidence map›Paper›PMID 31687530›Full record

ArticleHeliyon2019

Molecular docking analysis of apigenin and quercetin from ethylacetate fraction of

Akinwunmi O Adeoye, John O Olanlokun, Habib Tijani, Segun O Lawal, Cecilia O Babarinde, Mobolaji T Akinwole, Clement O Bewaji

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
23.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Educational Leadership for Sustainable Capacity Building Towards Enhancing Interdisciplinary Collaboration in Computer-Aided Drug Design and Network Pharmacology: A Systematic Review.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Akinwunmi O AdeoyeDepartment of Biochemistry, Federal University Oye Ekiti, Ekiti State, Nigeria.
John O OlanlokunBiomembrane and Biotechnology Laboratory, Department of Biochemistry, University of Ibadan, Oyo State, Nigeria.
Habib TijaniDepartment of Biochemistry, University of Ilorin, Kwara State, Nigeria.
Segun O LawalBiomembrane and Biotechnology Laboratory, Department of Biochemistry, University of Ibadan, Oyo State, Nigeria.
Cecilia O BabarindeBiomembrane and Biotechnology Laboratory, Department of Biochemistry, University of Ibadan, Oyo State, Nigeria.
Mobolaji T AkinwoleBiomembrane and Biotechnology Laboratory, Department of Biochemistry, University of Ibadan, Oyo State, Nigeria.
Clement O BewajiDepartment of Biochemistry, University of Ilorin, Kwara State, Nigeria.
University of Ibadan · NGUniversity of Ilorin · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe investigation and knowledge of calcium handling mechanisms in the plasmodium has been considered as a potential biological target against malaria.

objectiveThis study deals with the evaluation of inhibitory activity of secondary metabolites of ethylacetate partitioned-fraction of MATERIALS AND

methodsMolecular docking and virtual screening was performed to understand the mechanism of ligand binding and to identify potent calcium transporter inhibitors. The stem bark extracts of

resultsThe secondary metabolites, quercetin and apigenin inhibited the formation of β-hematin. The results showed that all the selected compounds in the

conclusionMolecular docking analysis could lead to further development of potent calcium transporter inhibitors for the prevention and treatment of malaria and related conditions.

Indexed as

AutoDock toolBiochemistryBiocomputational methodBioinformaticsComputational biologyComputer-aided drug designHPLC-DAD analysisHRGC-MS analysisMalariaPharmaceutical scienceSecondary metabolites

Identifiers

PMID31687530
PMCPMC6819832
OpenAlexW2974382858

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.