Evidence map›Paper›PMID 31687523›Full record

ArticleHeliyon2019

Influence of dioxin-related compounds on physical function in Yusho incident victims.

Jun-Ichi Fukushi, Hidetoshi Tsushima, Yoshihiro Matsumoto, Chikage Mitoma, Masutaka Furue, Hisaaki Miyahara, Yasuharu Nakashima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Underexplored terrain: effects of high priority environmental toxicants on skeletal muscle.Journal of toxicology and environmental health. Part B, Critical reviews · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jun-Ichi FukushiDepartment of Rheumatology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Jigyohama1-8-1, Chuoh-ku, Fukuoka 810-8583, Japan.
Hidetoshi TsushimaDepartment of Rheumatology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Jigyohama1-8-1, Chuoh-ku, Fukuoka 810-8583, Japan.
Yoshihiro MatsumotoDepartment of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Maidashi3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
Chikage MitomaDepartment of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
Masutaka FurueDepartment of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
Hisaaki MiyaharaDepartment of Rheumatology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Jigyohama1-8-1, Chuoh-ku, Fukuoka 810-8583, Japan.
Yasuharu NakashimaDepartment of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Maidashi3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
Kyushu University · JPNational Kyushu Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFew studies have examined the influence of dioxin-related compounds on human physical function, and existing results are inconsistent. In 1968, accidental human exposure to rice oil contaminated with dioxin-related compounds resulted in the development of Yusho oil disease in Japan. We aimed to determine whether the degree of exposure to dioxin-related compounds was associated with physical function in Yusho patients.

methodsIn 2016, 65 men (average age: 65.7 years) and 77 women (average age: 64.7 years) participated in a nationwide health examination in Fukuoka prefecture. Functional reach, gait speed, hand grip strength, and toe grip strength were evaluated as part of physical function. The serum levels of polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofurans, and non-ortho polychlorinated biphenyls were measured using high-resolution gas chromatography and high-resolution mass spectrometry. We examined the association between physical function tests and serum toxic equivalency (TEQ) values.

resultsA 10-fold increase in serum TEQ levels was negatively associated with functional reach (adjusted b = -4.07, p = 0.017) and hand grip strength (adjusted b = -2.20, p = 0.0245) in men. No association was observed between serum TEQ level and physical function in women.

conclusionOur findings suggest that dioxin-related compounds have a negative influence on physical function in men. However, these findings should be interpreted carefully. Future studies examining additional data on musculoskeletal disorders are warranted.

Indexed as

DioxinEnvironmental healthEnvironmental scienceEnvironmental toxicologyEpidemiologyFunctional reachHand grip strengthMusculoskeletal systemPhysical activityPhysical functionToxicologyYusho

Identifiers

PMID31687523
PMCPMC6820256
OpenAlexW2981678671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.