Evidence map›Paper›PMID 31687322›Full record

ArticleAnalytical cellular pathology (Amsterdam)2019

The Impact of Type II Diabetes on Tongue Dysplasia and p16-Related Aging Process: An Experimental Study.

Eren Altun, Hasmet Yazici, Erhan Arslan, Kamil Gokce Tulaci, Haydar Ali Erken

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eren AltunBalikesir University, Faculty of Medicine, Department of Pathology, Balikesir, Turkey.ORCID https://orcid.org/0000-0001-9110-8364
Hasmet YaziciBalikesir University, Faculty of Medicine Department of Otolaryngology, Balikesir, Turkey.
Erhan ArslanBalikesir University, Faculty of Medicine Department of Otolaryngology, Balikesir, Turkey.
Kamil Gokce TulaciBalikesir University, Faculty of Medicine Department of Otolaryngology, Balikesir, Turkey.
Haydar Ali ErkenBalikesir University, Faculty of Medicine Department of Physiology, Balikesir, Turkey.
Balıkesir University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the effect of streptozotocin-induced experimental diabetes mellitus on p16, p53, Ki67, and Bcl2 expressions and histopathological changes in the tongue of the rats. MATERIAL AND

methodsTwenty-two adult female Sprague-Dawley rats were used. The rats were randomly divided into 2 groups (

resultsSignificant differences were observed between the DM group and the control group in terms of epithelial thickness, length of filiform papillae, and width of filiform papillae (

conclusionsIn our study, streptozotocin-induced experimental diabetes mellitus induced p16 expression but did not show any difference in p53, Bcl-2, and Ki67 levels. It should be considered in the studies that the pathological changes at the early stages of the relationship between DM and oral cancer may be related to p16 expression; however, it may also be linked with p16-related aging process.

Indexed as

AgingAnimalsCyclin-Dependent Kinase Inhibitor p16Diabetes Mellitus, Type 2EpitheliumMaleRats, Sprague-DawleyTongueCyclin-Dependent Kinase Inhibitor p16

Identifiers

PMID31687322
PMCPMC6800967
OpenAlexW2979559345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.