Evidence map›Paper›PMID 31687321›Full record

ArticleNanotheranostics2019

Microbubble-enhanced ultrasound for the antivascular treatment and monitoring of hepatocellular carcinoma.

Julia C D'Souza, Laith R Sultan, Stephen J Hunt, Terence P Gade, Mrigendra B Karmacharya, Susan M Schultz, Angela K Brice, Andrew K W Wood, Chandra M Sehgal

Open access · goldAbstract read
In one paragraph

Article in Nanotheranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Article
  3. Delivery of Cavitation Therapy With a Modified Clinical Scanner: In Vitro Evaluation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025
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  18. Dose-dependent effects of ultrasound therapy on hepatocellular carcinoma.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Julia C D'SouzaUltrasound Research Laboratory, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.
Laith R SultanUltrasound Research Laboratory, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.
Stephen J HuntUltrasound Research Laboratory, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.
Terence P GadePenn Image-Guided Interventions Lab, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, 646 BRB II/III Philadelphia, PA 19104, USA.
Mrigendra B KarmacharyaUltrasound Research Laboratory, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.
Susan M SchultzUltrasound Research Laboratory, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.
Angela K BriceUniversity Laboratory Animal Resources, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA.
Andrew K W WoodDepartment of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104, USA.
Chandra M SehgalUltrasound Research Laboratory, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.
University of Pennsylvania · US

Funding

NRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0M
Antivascular ultrasound therapy of primary liver neoplasiaR01CA204446 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, CHANDRA M · 2017 to 2021
$2.0M
Tunable microbubbles for antivascular ultrasoundR01EB022612 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, CHANDRA M · 2016 to 2019
$1.6M
Integrated photoacoustic and ultrasound imaging with the Vevo LAZRS10OD016310 · OD · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, CHANDRA M · 2014 to 2014
$494k
NCATS NIH HHS TL1 TR001880NCI NIH HHS R01 CA204446NIBIB NIH HHS R01 EB022612NIH HHS S10 OD016310
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MicrobubblesUltrasonography, DopplerAlkylating AgentsAnimalsBlood VesselsCarcinoma, HepatocellularContrast MediaDiethylnitrosamineLiver NeoplasmsMaleRatsRats, WistarUltrasonic TherapyAlkylating AgentsContrast MediaDiethylnitrosamineantivascular ultrasoundHepatocellular carcinomanoninvasive cancer therapiespreclinical studies

Identifiers

PMID31687321
PMCPMC6821993
OpenAlexW2978437163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.