ArticlePeerJ2019
Serum-deprived differentiated neuroblastoma F-11 cells express functional dorsal root ganglion neuron properties.
Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Enzymatically Polymerized Organic Conductors on Native Lipid Membranes.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Development of a mammalian neurosensory full-thickness skin equivalent and its application to screen sensitizing stimuli.Bioengineering & translational medicine · 2023Article
- Lactate secreted via MCT4 from bone‑colonizing breast cancer excites sensory neurons via GPR81.International journal of oncology · 2023Article
- Pulsed Radiofrequency Decreases pERK and Affects Intracellular CaJournal of pain research · 2023Article
- Transcriptional profiling of neuronal ion channels in dorsal root ganglion-derived immortal cell line (F-11) under different culture conditions.In vitro models · 2022Article
- Prussian Blue Nanoparticle-Mediated Scalable Thermal Stimulation for In Vitro Neuronal Differentiation.Nanomaterials (Basel, Switzerland) · 2022Article
- Neoglycosylated Collagen: Effect on Neuroblastoma F-11 Cell Lines.Molecules (Basel, Switzerland) · 2020Article
- Immortalized Dorsal Root Ganglion Neuron Cell Lines.Frontiers in cellular neuroscience · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The isolation and culture of dorsal root ganglion (DRG) neurons cause adaptive changes in the expression and regulation of ion channels, with consequences on neuronal excitability. Considering that not all neurons survive the isolation and that DRG neurons are heterogeneous, it is difficult to find the cellular subtype of interest. For this reason, researchers opt for DRG-derived immortal cell lines to investigate endogenous properties. The F-11 cell line is a hybridoma of embryonic rat DRG neurons fused with the mouse neuroblastoma line N18TG2. In the proliferative condition, F-11 cells do not display a gene expression profile correspondent with specific subclasses of sensory neurons, but the most significant differences when compared with DRGs are the reduction of voltage-gated sodium, potassium and calcium channels, and the small amounts of
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