ArticleMultiple sclerosis international2019
Is There Any Relationship between Upper and Lower Limb Impairments in People with Multiple Sclerosis? A Kinematic Quantitative Analysis.
Article in Multiple sclerosis international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Effectiveness of Motor Imagery on Motor Recovery in Patients with Multiple Sclerosis: Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Are Isokinetic Torque-Angle Models Derived from Healthy Subjects Applicable to Patients with Upper-Limb Neurological Motor Impairment?Annals of biomedical engineering · 2026Trial
- Age-related changes in mobility assessments correlate with repetitive goal-directed arm-movement performance.BMC geriatrics · 2023Trial
- Slowing down in PNP: relationship of joint velocities in an arm-movement test and the fast TUG test.Scientific reports · 2025Article
- Spasticity patterns assessment and recognition for therapeutic approaches (SPARTA) in multiple sclerosis: a multicenter epidemiological study.Journal of neurology · 2024Article
- Fluctuations in Upper and Lower Body Movement during Walking in Normal Pressure Hydrocephalus and Parkinson's Disease Assessed by Motion Capture with a Smartphone Application, TDPT-GT.Sensors (Basel, Switzerland) · 2023Article
- Sensorimotor network dynamics predict decline in upper and lower limb function in people with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment.PloS one · 2022Article
- Digital Biomarkers in Multiple Sclerosis.Brain sciences · 2021Review
- Functional correlates of motor control impairments in multiple sclerosis: A 7 Tesla task functional MRI study.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn people with multiple sclerosis (pwMS), disability is generally assessed on the basis of ambulation abilities, whereas upper limb motor dysfunctions are less frequently considered. Nevertheless, they can severely affect the quality of life of pwMS. To date, it remains mostly unknown whether a relationship exists between upper and lower limb impairments.
aimTo investigate the existence of a relationship between upper and lower limb impairments in pwMS based on two fundamental motor tasks, namely walking and hand-to-mouth (HTM) movement.
methodsTwenty-eight pwMS with Expanded Disability Status Scale (EDSS) scores in the range of 1-6, and 21 healthy controls (HC) underwent a kinematic analysis of gait and HTM movement performed with a motion capture system. The spatiotemporal parameters for the two tasks were calculated and correlated using Spearman's rank correlation coefficients.
resultsThe pwMS performed worse than HC on both tasks. Small to large correlations were found between the total HTM movement duration and most of the gait parameters (rho, 0.35-0.68;
conclusionsBoth upper and lower limb motor abilities in pwMS worsen as disability increases. Nevertheless, their relationship is only moderate. This finding emphasizes the need for specific tests to quantify disability considering the overall motor function in pwMS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.