ArticleObesity science & practice2019
Changes in brain activity after weight loss.
Article in Obesity science & practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- The Interplay Between Psychological and Neurobiological Predictors of Weight Regain: A Narrative Review.Nutrients · 2025Review
- The effect of weight loss on brain age in schizophrenia spectrum disorders.PLOS mental health · 2025Article
- Low-calorie diet-induced weight loss is associated with altered brain connectivity and food desire in obesity.Obesity (Silver Spring, Md.) · 2024Article
- Current Insights into the Potential Role of fMRI in Discovering the Mechanisms Underlying Obesity.Journal of clinical medicine · 2023Review
- Intermittent energy restriction changes the regional homogeneity of the obese human brain.Frontiers in neuroscience · 2023Article
- Functional Magnetic Resonance Imaging and Obesity-Novel Ways to Seen the Unseen.Journal of clinical medicine · 2022Review
- Milk fat globule membrane attenuates high fat diet-induced neuropathological changes in obese Ldlr-/-.Leiden mice.International journal of obesity (2005) · 2022Article
- Whole-brain functional connectivity correlates of obesity phenotypes.Human brain mapping · 2020Article
- Obesity and Brain Function: The Brain-Body Crosstalk.Medicina (Kaunas, Lithuania) · 2020Review
- Changes in brain activity after weight loss.Obesity science & practice · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe importance of the regulatory role of the brain in directing glucose homeostasis, energy homeostasis, eating behaviour, weight control and obesity is increasingly recognized. Brain activity in (sub)cortical neuronal networks involved in homeostatic control and hedonic responses is generally increased in persons with obesity. Currently, it is not known if these functional changes can be affected by dieting. The aim of the current study was to investigate whether prolonged fasting and/or weight loss influences neuronal brain activity in obese persons.
methodsFourteen participants with obesity were included (two male participants and 12 female participants, body mass index 35.2 ± 1.2 kg m
resultsAn 8-week weight loss intervention decreased BOLD signal in areas of the brain involved in salience, sensory motor and executive control. BOLD signal in these areas correlated with leptin levels and body mass index.
conclusionsWeight loss decreased activity in brain areas involved in feeding behaviour and reward processing. These results indicate that these obesity-associated alterations in neuronal activity are related to excessive body weight and might change after weight loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.