Evidence map›Paper›PMID 31687060›Full record

ArticleThe annals of applied statistics2019

MULTILAYER KNOCKOFF FILTER: CONTROLLED VARIABLE SELECTION AT MULTIPLE RESOLUTIONS.

Eugene Katsevich, Chiara Sabatti

Abstract read
In one paragraph

Article in The annals of applied statistics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Catch me if you can: signal localization with knockoffJournal of the Royal Statistical Society. Series B, Statistical methodology · 2025
    Article
  6. Controlling the False Split Rate in Tree-Based Aggregation.Journal of the American Statistical Association · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Analysis of Microbiome Data.Annual review of statistics and its application · 2024
    Article
  11. Article
  12. Article
  13. False discovery rate control in genome-wide association studies with population structure.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eugene KatsevichDEPARTMENT OF STATISTICS, STANFORD UNIVERSITY, 390 SERRA MALL, STANFORD, CALIFORNIA 94305, ekatsevi@stanford.edu, sabatti@stanford.edu.
Chiara SabattiDEPARTMENT OF STATISTICS, STANFORD UNIVERSITY, 390 SERRA MALL, STANFORD, CALIFORNIA 94305, ekatsevi@stanford.edu, sabatti@stanford.edu.

Funding

Genomic and Metabolomic Profiling of Finnish Familial Dyslipidemia FamiliesR01HL113315 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B., PALOTIE, AARNO · 2012 to 2016
$3.4M
New Statistical Methods for High Resolution Mapping of Multiple PhenotypesR01HG006695 · NHGRI · STANFORD UNIVERSITY · PI SABATTI, CHIARA · 2013 to 2015
$1.0M
NHGRI NIH HHS R01 HG006695NHLBI NIH HHS R01 HL113315
6 · The paper itself

Abstract

We tackle the problem of selecting from among a large number of variables those that are "important" for an outcome. We consider situations where groups of variables are also of interest. For example, each variable might be a genetic polymorphism, and we might want to study how a trait depends on variability in genes, segments of DNA that typically contain multiple such polymorphisms. In this context, to discover that a variable is relevant for the outcome implies discovering that the larger entity it represents is also important. To guarantee meaningful results with high chance of replicability, we suggest controlling the rate of false discoveries for findings at the level of individual variables and at the level of groups. Building on the knockoff construction of Barber and Candès [

Indexed as

false discovery rate (FDR)genomewide association study (GWAS)group FDRknockoff filtermultiresolutionp-filterVariable selection

Identifiers

PMID31687060
PMCPMC6827557

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.