Evidence map›Paper›PMID 31687048›Full record

ArticleDisease markers2019

Inflammation-Related Patterns in the Clinical Staging and Severity Assessment of Chronic Kidney Disease.

Simona Mihai, Elena Codrici, Ionela D Popescu, Ana-Maria Enciu, Elena Rusu, Diana Zilisteanu, Laura G Necula, Gabriela Anton, Cristiana Tanase

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
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  10. Inflammatory biomarkers in staging of chronic kidney disease: elevated TNFR2 levels accompanies renal function decline.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
  11. Review
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  14. Frontiers in molecular biosciences · 2022
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  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Simona MihaiBiochemistry-Proteomics Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Sector 5, Bucharest, Romania.ORCID https://orcid.org/0000-0001-5624-2058
Elena CodriciBiochemistry-Proteomics Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Sector 5, Bucharest, Romania.ORCID https://orcid.org/0000-0002-5507-1020
Ionela D PopescuBiochemistry-Proteomics Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Sector 5, Bucharest, Romania.
Ana-Maria EnciuBiochemistry-Proteomics Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Sector 5, Bucharest, Romania.ORCID https://orcid.org/0000-0002-8122-1096
Elena RusuFundeni Clinic of Nephrology, Carol Davila University of Medicine and Pharmacy, Sos Fundeni 258, 022328 Sector 2, Bucharest, Romania.
Diana ZilisteanuFundeni Clinic of Nephrology, Carol Davila University of Medicine and Pharmacy, Sos Fundeni 258, 022328 Sector 2, Bucharest, Romania.
Laura G NeculaMolecular Virology Department, Stefan S. Nicolau Institute of Virology, Sos Mihai Bravu 285, 030304 Sector 3, Bucharest, Romania.
Gabriela AntonMolecular Virology Department, Stefan S. Nicolau Institute of Virology, Sos Mihai Bravu 285, 030304 Sector 3, Bucharest, Romania.
Cristiana TanaseBiochemistry-Proteomics Department, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, 050096 Sector 5, Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · ROInstitutul National Victor Babes · ROTitu Maiorescu University · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is an irreversible loss of kidney function, and it represents a major global public health burden due to both its prevalence and its continuously increasing incidence. Mineral bone disorders (MBDs) constitute a hallmark of CKD, and alongside cardiovascular complications, they underlie a poor prognosis for these patients. Thus, our study focused on novel CKD biomarker patterns and their impact on the clinical staging of the disease. As a first testing approach, the relative expression levels of 105 proteins were assessed by the Proteome Profiler Cytokine Array Kit for pooled CKD stage 2-4 serum samples to establish an overall view regarding the proteins involved in CKD pathogenesis. Among the molecules that displayed significant dysregulation in the CKD stages, we further explored the involvement of Dickkopf-related protein 1 (Dkk-1), a recognised inhibitor of the Wnt signalling pathway, and its crosstalk with 1,25OH

Indexed as

AgedAlgorithmsBiomarkersBone DensityBone DiseasesCalcitriolCross-Sectional StudiesFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsHumansInflammationIntercellular Signaling Peptides and ProteinsInterleukin-6MaleMiddle AgedBGLAP protein, humanBiomarkersCalcitriolDKK1 protein, humanFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsIL6 protein, humanIntercellular Signaling Peptides and ProteinsInterleukin-6OsteocalcinOsteopontinOsteoprotegerinProteomeSPP1 protein, humanTNFRSF11B protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID31687048
PMCPMC6800975
OpenAlexW2978134355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.