Evidence map›Paper›PMID 31686842›Full record

ArticleOncoTargets and therapy2019

LncRNA ELF3-AS1 is involved in the regulation of oral squamous cell carcinoma cell proliferation by reprogramming glucose metabolism.

Hongxing Chu, Zhengqiang Li, Zekun Gan, Zinan Yang, Zhenzhen Wu, Mingdeng Rong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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  7. Regulation of Ferroptosis by Non-Coding RNAs in Head and Neck Cancers.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hongxing Chu *Department of Periodontics and Implantology, Stomatological Hospital, Southern Medical University (Guangdong Provincial Stomatological Hospital), Guangzhou City, Guangdong Province 510280, People's Republic of China.
Zhengqiang Li *Department of Periodontics and Implantology, Stomatological Hospital, Southern Medical University (Guangdong Provincial Stomatological Hospital), Guangzhou City, Guangdong Province 510280, People's Republic of China.
Zekun GanDepartment of Periodontics and Implantology, Stomatological Hospital, Southern Medical University (Guangdong Provincial Stomatological Hospital), Guangzhou City, Guangdong Province 510280, People's Republic of China.
Zinan YangDepartment of Periodontics and Implantology, Stomatological Hospital, Southern Medical University (Guangdong Provincial Stomatological Hospital), Guangzhou City, Guangdong Province 510280, People's Republic of China.
Zhenzhen WuDepartment of Periodontics and Implantology, Stomatological Hospital, Southern Medical University (Guangdong Provincial Stomatological Hospital), Guangzhou City, Guangdong Province 510280, People's Republic of China.
Mingdeng RongDepartment of Periodontics and Implantology, Stomatological Hospital, Southern Medical University (Guangdong Provincial Stomatological Hospital), Guangzhou City, Guangdong Province 510280, People's Republic of China.
Southern Medical University · CNGuangdong Province Stomatological Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe present study aims to investigate the role of ELF3-AS1 in oral squamous cell carcinoma (OSCC). PATIENTS AND

methodsA total of 112 patients with OSCC were admitted in Guangdong Provincial Stomatological Hospital from March 2016 to March 2019. RT-qPCR, cells and transient transfections, cell proliferation rate measurements and Western blots were carried out to analyze the samples.

resultsIn the present study, we showed that ELF3-AS1 and glucose transporter 1 (GLUT1) were both upregulated in OSCC tissues, and those two factors were positively correlated. In OSCC cells, ELF3-AS1 overexpression resulted in upregulation, while ELF3-AS1 siRNA silencing caused downregulated expression of GLUT1 and glucose uptake. ELF3-AS1 and GLUT1 overexpression resulted in increased rate of OSCC cells, while ELF3-AS1 and GLUT1 siRNA silencing resulted in decreased proliferation rate of OSCC cells. In addition, GLUT1 siRNA silencing attenuated the effects of ELF3-AS1 overexpression.

conclusionTherefore, ELF3-AS1 promotes the proliferation of OSCC cells by reprogramming glucose metabolism.

Indexed as

glucose uptakeGLUT1lncRNA ELF3-AS1oral squamous cell carcinoma

Identifiers

PMID31686842
PMCPMC6709795
OpenAlexW2969273170

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.