ArticleAdvanced materials (Deerfield Beach, Fla.)2020
Chiral Supraparticles for Controllable Nanomedicine.
Article in Advanced materials (Deerfield Beach, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed.
- Roadmap for light interaction with biophotonic surfaces and their diverse applications.Journal of biomedical optics · 2026Article
- A Chiral 2D Sheet for Enhancing GLUT1 Function Through the Interplay of Architecture and Recognition.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Dynamics and Conformational Stability of Chiral Bay-Phenolate-Substituted Twisted Octaazaperopyrenedioxides (OAPPDOs).Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Biomolecule-tailored chiral nickel oxide nanozymes amplify autophagy-mediated tumor ablation via synergistic photodynamic-chemodynamic therapy.Materials today. Bio · 2025Article
- The Overlooked Stereoisomers of the Ionizable Lipid ALC315.Journal of the American Chemical Society · 2025Article
- A basedMaterials today. Bio · 2025Article
- Optically tunable catalytic cancer therapy using enzyme-like chiral plasmonic nanoparticles.Nature communications · 2025Article
- Stereoselective Interactions of Chiral Polyurea Nanocapsules with Albumins.ACS applied materials & interfaces · 2024Article
- Supramolecular Chiral Binding Affinity-Achieved Efficient Synergistic Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Controlling supramolecular copolymerization of alkynylplatinum(ii) terpyridine complexes: from isodesmic to cooperative mechanisms.Nanoscale advances · 2024Article
- Considering the impact of the chirality of therapeutic nanoparticles on cancer therapy.Nanomedicine (London, England) · 2024Article
- Turning chiral peptides into a racemic supraparticle to induce the self-degradation of MDM2.Journal of advanced research · 2023Article
- Chirality-enhanced transport and drug delivery of graphene nanocarriers to tumor-like cellular spheroid.Frontiers in chemistry · 2023Article
- Chirality-controlled polymerization-induced self-assembly.Chemical science · 2022Article
- Understanding the immunological interactions of engineered nanomaterials: Role of the bio-corona.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
- Chiral Biomaterials for Nanomedicines: From Molecules to Supraparticles.Pharmaceutics · 2022Review
- In situ analysis of nanoparticle soft corona and dynamic evolution.Nature communications · 2022Article
- Recent advances in chiral nanomaterials with unique electric and magnetic properties.Nano convergence · 2022Review
- Helicity-driven chiral self-sorting supramolecular polymerization with AgChemical science · 2022Article
- Chirality at nanoscale for bioscience.Chemical science · 2022Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Chirality is ubiquitous in nature and hard-wired into every biological system. Despite the prevalence of chirality in biological systems, controlling biomaterial chirality to influence interactions with cells has only recently been explored. Chiral-engineered supraparticles (SPs) that interact differentially with cells and proteins depending on their handedness are presented. SPs coordinated with d-chirality demonstrate greater than threefold enhanced cell membrane penetration in breast, cervical, and multiple myeloma cancer cells. Quartz crystal microbalance with dissipation and isothermal titration calorimetry measurements reveal the mechanism of these chiral-specific interactions. Thermodynamically, d-SPs show more stable adhesion to lipid layers composed of phospholipids and cholesterol compared to l-SPs. In vivo, d-SPs exhibit superior stability and longer biological half-lives likely due to opposite chirality and thus protection from endogenous proteins including proteases. This work shows that incorporating d-chirality into nanosystems enhances uptake by cancer cells and prolonged in vivo stability in circulation, providing support for the importance of chirality in biomaterials. Thus, chiral nanosystems may have the potential to provide a new level of control for drug delivery systems, tumor detection markers, biosensors, and other biomaterial-based devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.