ArticleJournal of microbiology (Seoul, Korea)2019
Vibrio parahaemolyticus cqsA controls production of quorum sensing signal molecule 3-hydroxyundecan-4-one and regulates colony morphology.
Article in Journal of microbiology (Seoul, Korea), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Bacterial quorum-sensing systems in cell-cell communication.FEMS microbiology reviews · 2026Review
- LtrB inhibitsCurrent research in food science · 2026Article
- Antimicrobial resistance, virulence factors and phylogenetic profiles ofFrontiers in microbiology · 2024Article
- A novel finding of intra-genus inhibition of quorum sensing in Vibrio bacteria.Scientific reports · 2022Article
- Supplementation of ex situ produced bioflocs improves immune response against AHPND in Pacific whiteleg shrimp (Litopenaeus vannamei) postlarvae.Applied microbiology and biotechnology · 2022Article
- Dynamics and Microevolution ofmSystems · 2021Article
- Adaptations ofFrontiers in microbiology · 2021Review
- Identification of LuxR Family Regulators That Integrate Into Quorum Sensing Circuit inFrontiers in microbiology · 2021Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to adapt to different environments, Vibrio parahaemolyticus employed a complicated quorum sensing system to orchestrate gene expression and diverse colony morphology patterns. In this study, the function of the putative quorum sensing signal synthase gene cqsA (VPA0711 in V. Parahaemolyticus strain RIMD2210633 genome) was investigated. The cloning and expression of V. parahaemolyticus cqsA in Escherichia coli system induced the production of a new quorum sensing signal that was found in its culture supernatant. The signal was purified by high performance liquid chromatography methods and determined to be 3-hydroxyundecan- 4-one by indirect and direct mass spectra assays. The deletion of cqsA in RIMD2210633 changed V. parahaemolyticus colony morphology from the classical 'fried-egg' shape (thick and opaque in the center, while thin and translucent in the edge) of the wild-type colony to a 'pancake' shape (no significant difference between the centre and the edge) of the cqsA deleted colony. This morphological change could be restored by complementary experiment with cqsA gene or the signal extract. In addition, the expression of opaR, a well-known quorum sensing regulatory gene, could be up-regulated by cqsA deletion. Our results suggested that V. parahaemolyticus used cqsA to produce 3-hydroxyundecan-4-one signal and thereby regulated colony morphology and other quorum sensing-associated behaviors.
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