Evidence map›Paper›PMID 31686277›Full record

SynthesisThe international journal of cardiovascular imaging2020

Pooled summary of native T1 value and extracellular volume with MOLLI variant sequences in normal subjects and patients with cardiovascular disease.

Ha Q Vo, Thomas H Marwick, Kazuaki Negishi

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The international journal of cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Cardiovascular magnetic resonance native T1 mapping in Anderson-Fabry disease: a systematic review and meta-analysis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ha Q VoMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Thomas H MarwickMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Kazuaki NegishiMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Kazuaki.Negishi@sydney.edu.au.ORCID http://orcid.org/0000-0002-9086-2565
University of Tasmania · AU

Funding

Heart Foundation 101868
6 · The paper itself

Abstract

T1 mapping by cardiac magnetic resonance (CMR) allows detection of abnormal myocardium. A number of myocardial abnormalities affects the signal captured in T1 mapping. We performed a systematic review and meta-analysis of native T1 and extracellular volume (ECV) in subjects with and without cardiac disease (1) to determine the normal ranges of T1 values and ECV by sequences as well as parameters influencing them, and (2) to summarize the differences in T1 values and ECV of the diseases relative to the normal ranges. Three databases (EMBASE, SCOPUS, and MEDLINE) were systematically searched for native T1 time and ECV. Only human studies with a sample size of ≥ 20 subjects were included. A random effect model was used to pool data. The 69 selected articles included 1954 healthy subjects and 3186 with disease. T1 of normal healthy was different among MOLLI variants: in 1.5T sequences, ShMOLLI had the shortest (944 ms [95% confidence interval 925, 963]), followed by MOLLI 3(3)3(3)5 flip-angle 50°, 967 [959, 975] and flip-angle 35°, 969 [951, 988]. 3T had longer T1 than 1.5T by approximately 100-200 ms. ECV of the normal healthy was consistent among the studies (ranging from 25 to 27%), irrespective of subjects' factors, sequences, vendors, and contrast type. Many diseases demonstrated longer native T1 than normal subjects, but T1 was shorter in Fabry disease and iron overload. In contrast, all disease states showed either normal or increased ECV. Diagnostic accuracy of native T1 time was minimally affected by the difference in the sequences. ECV is less influenced by methodology than T1 time among normal subjects. Different myocardial diseases are associated with shorter or longer T1 times, whereas ECV is consistently increased independent of the underlying pathophysiology.

Indexed as

Magnetic Resonance ImagingCardiovascular DiseasesDiagnosis, DifferentialFibrosisHumansMyocardiumPredictive Value of TestsDiseaseECVMeta-analysisNormal valueT1 mapping

Identifiers

PMID31686277
OpenAlexW2987823824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.