ArticleInternational journal of colorectal disease2020
Lung metastasectomy after colorectal cancer: prognostic impact of resection margin on long term survival, a retrospective cohort study.
Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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27 citing papers in PubMed, 37 citations in OpenAlex.
- Article
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- Computed tomography-guided lipiodol marking enables margin-secure wedge resection for colorectal pulmonary metastases.Journal of thoracic disease · 2025Article
- Extrapulmonary metastases impact survival outcomes of thermal ablation for colorectal lung oligometastases: A multicenter study.World journal of gastroenterology · 2025Article
- Pulmonary Metastasectomy for Colorectal Cancer: Evidence and Outcomes-A Narrative Review.Journal of clinical medicine · 2025Review
- Cryoablation for treatment of peripheral lung metastases from colorectal cancer: a bicenter retrospective study.European radiology · 2025Article
- Treatment outcomes and prognostic factors in patients with colorectal cancer and synchronous lung metastases in the conversion therapy era.International journal of colorectal disease · 2025Article
- Organotropic metastasis in colorectal cancer: integrating molecular pathways with therapeutic opportunities.Frontiers in immunology · 2025Review
- Adjuvant chemotherapy for isolated resectable colorectal lung metastasis: A retrospective study using inverse probability treatment weighting propensity analysis.World journal of gastrointestinal surgery · 2024Article
- Surgery for Infrarenal Retroperitoneal Node Metastases from Colon Cancer.Journal of gastrointestinal cancer · 2024Article
- Prognostic Relevance of Recurrent Sites of Gastric Cancer Treated With Curative Resection: A Single Center Retrospective Study.Journal of gastric cancer · 2024Article
- Optimizing Treatment Strategy for Oligometastases/Oligo-Recurrence of Colorectal Cancer.Cancers · 2023Review
- Oligometastatic Colorectal Cancer: A Review of Definitions and Patient Selection for Local Therapies.Journal of gastrointestinal cancer · 2023Review
- Contemporary Outcomes for the Curative Treatment of Colorectal Cancer Pulmonary Metastases.Journal of gastrointestinal cancer · 2023Article
- Results of intention-to-treat pulmonary metastasectomies in northern Finland revealing significant number of new lung primary carcinomas: time to move on from wedge resections?Journal of thoracic disease · 2023Article
- Stereotactic ablative body radiation therapy for isolated pulmonary metastases from pancreatic cancer after metastectomy with positive margins: a case report.Journal of medical case reports · 2023Article
- Key points in pulmonary metastasectomy from colorectal carcinoma: European Society of Thoracic Surgeons survey analysis.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- The extent of pulmonary resection for lung metastases from colorectal cancer.Journal of thoracic disease · 2022Article
- Impact of the extent of lung resection on postoperative outcomes of pulmonary metastasectomy for colorectal cancer metastases: an exploratory systematic review.Journal of thoracic disease · 2022Review
- Local Therapies in Advanced Colorectal Cancer.Hematology/oncology clinics of North America · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary metastasectomy is considered a potentially curative treatment for selected patients with metastatic colorectal cancer (CRC). Several prognostic factors have been analysed, but to date, it is still not well defined which is the optimal resection margin during lung metastasectomy (LM). This study analyses the long-term results and prognostic factors after LM in CRC patients with particular attention to the resection margins. Primary endpoint of this study is to assess the correlation between resection margins and long-term outcomes.
methodsObservational cohort study on all proven cases of CRC lung metastases (2000-2016) resected with curative intent in a single centre.
resultsThe series included 210 consecutive patients (M/F 133/77) with a mean age of 65.4 (± 9.96) years, 75% (159/210) of them with a solitary metastasis. Mean size of metastasis was 2.57 cm (± 1.45). One hundred sixty-eight patients underwent wedge resections (80%) and lymphadenectomy was carried out in 90 cases (42.9%). With a mean follow-up of 56 months (range 5-192), we observed a 1-, 3- and 5-year overall survival (OS) of 95%, 74% and 54%, respectively. The patients were divided into three groups according to the resection margin distance from the tumour: (a) ≥ 2 cm (145 cases); (b) < 2, ≥ 1 cm (37 cases); and (c) < 1 cm (12 cases). The OS was significantly different between the three groups (p = 0,020); univariate and multivariate analyses showed that a narrow resection margin was an independent prognostic factor of worse survival (p = 0.006 and HR 3.4 p = 0.009).
conclusionsLong-term survival of patients after LM is strongly associated with a greater distance between the lesion and the resection margin.
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