Evidence map›Paper›PMID 31686194›Full record

ArticleVirchows Archiv : an international journal of pathology2019

Novel markers in pediatric-type follicular lymphoma.

Claudio Agostinelli, Ayse U Akarca, Alan Ramsay, Hasan Rizvi, Manuel Rodriguez-Justo, Sabine Pomplun, Ian Proctor, Elena Sabattini, David Linch, Stephen Daw and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Pediatric-type follicular lymphoma: a short review.International journal of hematologic oncology · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Non Hodgkin Lymphoma Among Children: Pathological Aspects and Diagnostic Challenges.Clinical pathology (Thousand Oaks, Ventura County, Calif.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Claudio AgostinelliHaematopathology Unit, Department of Experimental Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Ayse U AkarcaDepartment of Pathology, University College London, London, UK.
Alan RamsayDepartment of Cellular Pathology, University College Hospital London, London, UK.
Hasan RizviDepartment of Cellular Pathology, Barts Health NHS Trust, London, UK.
Manuel Rodriguez-JustoDepartment of Pathology, University College London, London, UK.
Sabine PomplunDepartment of Cellular Pathology, University College Hospital London, London, UK.
Ian ProctorDepartment of Cellular Pathology, University College Hospital London, London, UK.
Elena SabattiniHaematopathology Unit, Department of Experimental Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
David LinchDepartment of Haematology, University College London Cancer Institute, London, UK.
Stephen DawChildren and Young People's Cancer Service, University College Hospital London, London, UK.
Stefania PittalugaHaematology section, Laboratory of Pathology, Center for Cancer Research National Cancer Institute, Bethesda, MD, USA.
Stefano A PileriDivision of Haematopathology, European Institute of Oncology, University Hospital of Tübingen, Institute of Pathology, Tübingen, Germany.
Elaine S JaffeHaematology section, Laboratory of Pathology, Center for Cancer Research National Cancer Institute, Bethesda, MD, USA.
Leticia Quintanilla-MartinezUniversity Hospital of Tübingen, Institute of Pathology, Tübingen, Germany.
Teresa MarafiotiDepartment of Pathology, University College London, London, UK. t.marafioti@ucl.ac.uk.
University College London · GBCenter for Cancer Research · USUniversity College Hospital · GBBarts Health NHS Trust · GBPoliclinico S.Orsola-Malpighi · ITUniversity Children's Hospital Tübingen · DEUniversity of Bologna · IT

Funding

Associazione Italiana per la Ricerca sul Cancro 21198
6 · The paper itself

Abstract

The aim of this study was to review the histopathological, phenotypic, and molecular characteristics of pediatric-type follicular lymphoma (PTFL) and to assess the diagnostic value of novel immunohistochemical markers in distinguishing PTFL from follicular hyperplasia (FH). A total of 13 nodal PTFLs were investigated using immunohistochemistry, fluorescence in situ hybridization (FISH), and PCR and were compared with a further 20 reactive lymph nodes showing FH. Morphologically, PTFL cases exhibited a follicular growth pattern with irregular lymphoid follicles in which the germinal centers were composed of numerous blastoid cells showing a starry-sky appearance. Immunohistochemistry highlighted preserved CD10 (13/13) and BCL6 (13/13) staining, CD20 (13/13) positivity, a K light chain predominance (7/13), and partial BCL2 expression in 6/13 cases (using antibodies 124, E17, and SP66). The germinal center (GC)-associated markers stathmin and LLT-1 were positive in most of the cases (12/13 and 12/13, respectively). Interestingly, FOXP-1 was uniformly positive in PTFL (12/13 cases) in contrast to reactive GCs in FH, where only a few isolated positive cells were observed. FISH revealed no evidence of BCL2, BCL6, or MYC rearrangements in the examined cases. By PCR, clonal immunoglobulin gene rearrangements were detected in 100% of the tested PTFL cases. Our study confirmed the unique morphological and immunophenotypic features of PTFL and suggests that FOXP-1 can represent a novel useful diagnostic marker in the differential diagnosis between PTFL and FH.

Indexed as

AdolescentAdultChildDiagnosis, DifferentialForkhead Transcription FactorsHumansImmunohistochemistryImmunophenotypingLymphoma, B-CellLymphoma, FollicularMaleRepressor ProteinsStathminYoung AdultForkhead Transcription FactorsFOXP1 protein, humanRepressor ProteinsStathminSTMN1 protein, humanDifferential diagnosisFOXP-1ImmunohistochemistryPediatric-type follicular lymphoma

Identifiers

PMID31686194
PMCPMC6881426
OpenAlexW2984482841

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.