SynthesisJournal of neurology2020
Cardiorespiratory fitness as a quantitative predictor of the risk of stroke: a dose-response meta-analysis.
Synthesis in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Cardiorespiratory fitness and health in children and adolescents: an overview of systematic reviews with meta-analyses representing over 125 000 observations covering 33 health-related outcomes.British journal of sports medicine · 2025Pooled it
- Cardiorespiratory fitness is a strong and consistent predictor of morbidity and mortality among adults: an overview of meta-analyses representing over 20.9 million observations from 199 unique cohort studies.British journal of sports medicine · 2024Pooled it
- Aerobic Fitness and Health-Related Phenotypes: A Two-Stage Phenome-Wide Mendelian Randomization Study.Medicine and science in sports and exercise · 2026Article
- Baseline functional oxygen uptake gain as a prognostic factor of center-based exercise responding in well-functioning older adults.European journal of physical and rehabilitation medicine · 2025Article
- The association between physical fitness and mental health among college students: a cross-sectional study.Frontiers in public health · 2024Observational
- Measurement of Physical Fitness and 24/7 Physical Activity, Standing, Sedentary Behavior, and Time in Bed in Working-Age Finns: Study Protocol for FINFIT 2021.Methods and protocols · 2022Article
- Can Anthropometry and Body Composition Explain Physical Fitness Levels in School-Aged Children?Children (Basel, Switzerland) · 2021Article
- Neurologic and Immunologic Complications of COVID-19: Potential Long-Term Risk Factors for Alzheimer's Disease.Journal of Alzheimer's disease reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeCardiorespiratory fitness (CRF) is closely related to our health, but whether high cardiorespiratory fitness could reduce stroke risk remains controversial. We used a meta-analysis to examine the overall association between cardiorespiratory fitness and stroke incidence.
methodsA systematic search was performed in PubMed, EMBASE, and Web of science. We estimated the overall relative risk (RR) of stroke incidence for high levels of CRF individuals versus individuals with low levels of CRF. Meanwhile, we made a quantitative analysis of the association between CRF and the risk of stroke.
results14 cohort studies containing 1,409,340 participants were included in this meta-analysis, and 23,894 stroke patients were observed. The meta-analysis documented that the high-CRF individuals had a 42% lower risk of stroke (RR_0.58; 95% CI 0.51-0.66) compared with low-CRF individuals. Besides, subgroup analysis showed that the inverse association of CRF with the risk of stroke was consistent. There are 29% lower risk of ischemic stroke (RR_0.71; 95% CI 0.54-0.93) and 31% lower risk of hemorrhagic stroke (RR_0.69; 95% CI 0.47-1.00). Dose-response analysis showed that every "unit-dose" increment of five metabolic equivalents (METs) reduced a 15% lower risk of stroke (RR_0.85; 95% CI 0.79-0.91).
conclusionThis meta-analysis provides the evidence that better CRF was with a lower risk of stroke incidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.