ArticleNature medicine2019
In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages.
Open access · greenAbstract read
In one paragraph
Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- Modest increase in the de novo single-nucleotide mutation rate in house mice born by assisted reproduction.Genome research · 2026Article
- Increased rate ofbioRxiv : the preprint server for biology · 2025Article
- Article
- Bioinformatics analysis of shared biomarkers and immune pathways of preeclampsia and periodontitis.BMC pregnancy and childbirth · 2025Article
- Parental and cell-division origin analysis to reduce false-positives in mosaic embryos for preimplantation genetic testing.Human reproduction open · 2025Article
- Article
- Human embryos harbor complex mosaicism with broad presence of aneuploid cells during early development.Cell discovery · 2024Article
- Clinical-grade whole genome sequencing-based haplarithmisis enables all forms of preimplantation genetic testing.Nature communications · 2024Article
- Differential expression of ion channel coding genes in the endometrium of women experiencing recurrent implantation failures.Scientific reports · 2024Article
- Mechanism of chromosomal mosaicism in preimplantation embryos and its effect on embryo development.Journal of assisted reproduction and genetics · 2024Review
- Expanding the PRAAS spectrum: De novo mutations of immunoproteasome subunit β-type 10 in six infants with SCID-Omenn syndrome.American journal of human genetics · 2024Article
- Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight.Nature communications · 2024Article
- Single-cell DNA sequencing reveals a high incidence of chromosomal abnormalities in human blastocysts.The Journal of clinical investigation · 2024Article
- Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss.Nature medicine · 2023Article
- The effect of embryonic genome imbalances on pregnancy.Nature medicine · 2023Article
- The rate of de novo structural variation is increased in in vitro-produced offspring and preferentially affects the paternal genome.Genome research · 2023Article
- Comparison of Genetic Profiles of Neonates in Intensive Care Units Conceived With or Without Assisted Reproductive Technology.JAMA network open · 2023Article
- The human embryonic genome is karyotypically complex, with chromosomally abnormal cells preferentially located away from the developing fetus.Human reproduction (Oxford, England) · 2023Article
- On the reproductive capabilities of aneuploid human preimplantation embryos.American journal of human genetics · 2022Review
- Single-cell multiomics sequencing reveals the reprogramming defects in embryos generated by round spermatid injection.Science advances · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 7 institutions in 8 countries.
Masoud Zamani Esteki *Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, the Netherlands. masoud.zamaniesteki@mumc.nl.ORCID http://orcid.org/0000-0003-3909-0050
Triin Viltrop *Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Olga Tšuiko *Centre for Human Genetics, University Hospital Leuven, Department of Human Genetics, KU Leuven, Leuven, Belgium.
Airi TiiratsDepartment of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Mariann KoelDepartment of Cell Biology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Margit NõukasDepartment of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Olga ŽilinaDepartment of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Katre TeearuDepartment of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Heidi MarjonenDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-5595-9946
Hanna KahilaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jeroen MeekelsDepartment of Clinical Genetics, Maastricht University Medical Centre, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0001-9343-784X
Viveca Söderström-AnttilaVäestöliitto Fertility Clinic, Helsinki, Finland.
Anne-Maria SuikkariVäestöliitto Fertility Clinic, Helsinki, Finland.
Aila TiitinenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Sulev KõksCenter for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, Western Australia, Australia.ORCID http://orcid.org/0000-0001-6087-6643
Nina Kaminen-AholaDepartment of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-1255-4716
Ants KurgDepartment of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-0829-1987
Thierry VoetCentre for Human Genetics, University Hospital Leuven, Department of Human Genetics, KU Leuven, Leuven, Belgium. thierry.voet@kuleuven.be.ORCID http://orcid.org/0000-0003-1204-9963
Joris Robert VermeeschCentre for Human Genetics, University Hospital Leuven, Department of Human Genetics, KU Leuven, Leuven, Belgium. joris.vermeesch@kuleuven.be.ORCID http://orcid.org/0000-0002-3071-1191
Andres SalumetsDepartment of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia. andres.salumets@ccht.ee.ORCID http://orcid.org/0000-0002-1251-8160
University of Tartu · EEUniversity of Helsinki · FIMaastricht University Medical Centre · NLVäestöliitto · FICentre For Human Genetics · INMurdoch University · AUWellcome Sanger Institute · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although chromosomal instability (CIN) is a common phenomenon in cleavage-stage embryogenesis following in vitro fertilization (IVF)
Indexed as
BlastocystCell LineageChromosomal InstabilityDNA Copy Number VariationsEmbryo, MammalianEmbryonic DevelopmentFemaleFertilization in VitroFetusGenotypeHumansInfant, NewbornMalePlacentaPolymorphism, Single NucleotidePregnancy
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.