Evidence map›Paper›PMID 31685994›Full record

ArticleNature cell biology2019

CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth.

Victoria M-Y Wang, Rute M M Ferreira, Jorge Almagro, Theodore Evan, Nathalie Legrave, May Zaw Thin, David Frith, Joana Carvalho, David J Barry, Ambrosius P Snijders and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 141 citations in OpenAlex.

  1. Article
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  12. Proteomics in pancreatic cancer.Biomarker research · 2025
    Review
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  15. Article
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Victoria M-Y Wang *Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-2657-6118
Rute M M Ferreira *Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.
Jorge AlmagroAdult Stem Cell Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-0652-6447
Theodore EvanAdult Stem Cell Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-8326-900X
Nathalie LegraveMetabolomics Laboratory, The Francis Crick Institute, London, UK.
May Zaw ThinAdult Stem Cell Laboratory, The Francis Crick Institute, London, UK.
David FrithProtein Analysis and Proteomics Laboratory, The Francis Crick Institute, London, UK.
Joana CarvalhoExperimental Histopathology Laboratory, The Francis Crick Institute, London, UK.
David J BarryAdvanced Light Microscopy Facility, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-2763-5244
Ambrosius P SnijdersProtein Analysis and Proteomics Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-5416-8592
Eleanor HerbertDepartment of Pathobiology & Population Sciences, Royal Veterinary College, Hatfield, UK.
Emma L NyeExperimental Histopathology Laboratory, The Francis Crick Institute, London, UK.
James I MacRaeMetabolomics Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-1464-8583
Axel BehrensAdult Stem Cell Laboratory, The Francis Crick Institute, London, UK. axel.behrens@crick.ac.uk.ORCID http://orcid.org/0000-0002-1557-1143
The Francis Crick Institute · GBKing's College London · GBRoyal Veterinary College · GB

Funding

Cancer Research UK FC001039Medical Research Council MC_PC_17179Wellcome Trust FC001039
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) shows great cellular heterogeneity, with pronounced epithelial and mesenchymal cancer cell populations. However, the cellular hierarchy underlying PDAC cell diversity is unknown. Here we identify the tetraspanin CD9 as a marker of PDAC tumour-initiating cells. CD9

Indexed as

Gene Expression Regulation, NeoplasticAmino Acid Transport System ASCAnimalsCarcinoma, Pancreatic DuctalCell Line, TumorCell MovementCell ProliferationGlutamineHumansMaleMiceMice, Inbred C57BLMice, TransgenicMinor Histocompatibility AntigensNeoplastic Stem CellsOrganoidsAmino Acid Transport System ASCCD9 protein, humanGlutamineMinor Histocompatibility AntigensSLC1A5 protein, humanTetraspanin 29

Identifiers

PMID31685994
PMCPMC6944508
OpenAlexW2983199633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.