ArticleNature cell biology2019
Differential scaling between G1 protein production and cell size dynamics promotes commitment to the cell division cycle in budding yeast.
Article in Nature cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 87 citations in OpenAlex.
- uORF-mediated translational control of CAK and Cdk activation in response to low nutrients in yeast.EMBO reports · 2026Article
- Cell cycle-dependent protein dynamics in budding yeast resolved by deconvolution of bulk proteomics.Molecular systems biology · 2026Article
- Experimental evolution of cellular miniaturization reveals a putative mechanism for cell size evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription.Cell reports · 2026Article
- RNA-specific local translation is patterned by condensates for multinucleate cell growth.Nature cell biology · 2026Article
- Interplay Between Ribosomal Gene Deficiency and Calorie Restriction in Shaping Yeast Biosynthetic Capacity.Cells · 2025Article
- A Fkh1/2 binding site array in thebioRxiv : the preprint server for biology · 2025Article
- Article
- A growing problem: The many unsolved mysteries of cell growth.Molecular biology of the cell · 2025Review
- Article
- Extending the G1 phase improves the production of lipophilic compounds in yeast by boosting enzyme expression and increasing cell size.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The "weaken-fill-repair" model for cell budding: Linking cell wall biosynthesis with mechanics.iScience · 2024Article
- Modeling the START transition in the budding yeast cell cycle.PLoS computational biology · 2024Article
- Article
- Mechanisms of cell size regulation in slow-growing Escherichia coli cells: discriminating models beyond the adder.NPJ systems biology and applications · 2024Article
- Evidence for novel mechanisms that control cell-cycle entry and cell size.Molecular biology of the cell · 2024Article
- Article
- Patterns of protein synthesis in the budding yeast cell cycle: variable or constant?Microbial cell (Graz, Austria) · 2024Article
- Mitochondrial membrane potential acts as a retrograde signal to regulate cell cycle progression.Life science alliance · 2023Article
- TOR Complex 1: Orchestrating Nutrient Signaling and Cell Cycle Progression.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the unicellular eukaryote Saccharomyces cerevisiae, Cln3-cyclin-dependent kinase activity enables Start, the irreversible commitment to the cell division cycle. However, the concentration of Cln3 has been paradoxically considered to remain constant during G1, due to the presumed scaling of its production rate with cell size dynamics. Measuring metabolic and biosynthetic activity during cell cycle progression in single cells, we found that cells exhibit pulses in their protein production rate. Rather than scaling with cell size dynamics, these pulses follow the intrinsic metabolic dynamics, peaking around Start. Using a viral-based bicistronic construct and targeted proteomics to measure Cln3 at the single-cell and population levels, we show that the differential scaling between protein production and cell size leads to a temporal increase in Cln3 concentration, and passage through Start. This differential scaling causes Start in both daughter and mother cells across growth conditions. Thus, uncoupling between two fundamental physiological parameters drives cell cycle commitment.
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