ArticleNature human behaviour2020
Overanxious and underslept.
Article in Nature human behaviour, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05026541 (Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators), which is not on this map. Cited by 96 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators
Who cites it
96 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The anxiolytic effect of dexmedetomidine in adult perioperative patients: a systematic review with meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2026Pooled it
- Association of sleep quality and sleep duration with anxiety symptoms in older adults: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Monitoring Daily Sleep, Mood, and Affect Using Digital Technologies and Wearables: A Systematic Review.Sensors (Basel, Switzerland) · 2024Pooled it
- Emotional Processing Following Digital Cognitive Behavioral Therapy for Insomnia in People With Depressive Symptoms: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Trial
- Bifidobacterium longum 1714 improves sleep quality and aspects of well-being in healthy adults: a randomized, double-blind, placebo-controlled clinical trial.Scientific reports · 2024Trial
- Trait anxiety selectively amplifies reward learning under uncertainty, while N3 sleep attenuates it.iScience · 2026Article
- Phenotypic Variability in Slow-Wave Sleep in Depression: Associations With Clinical Profiles and Disorder Severity.Journal of sleep research · 2026Article
- Sleep lowers waking theta frequency in the rat hippocampus.Cell reports · 2026Article
- Longitudinal Trajectories of Cognitive Control and Theory of Mind in Amnestic and Non-Amnestic Mild Cognitive Impairment: Prospective Associations of Objective Sleep Duration.Journal of clinical medicine · 2026Article
- Heart Rate Variability Moderates the Association Between Trait Anxiety and Sympathetic Nerve Activity in Humans.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Depression symptoms are associated with affective neural processing during sleep and rest.bioRxiv : the preprint server for biology · 2026Article
- Impaired slow-wave sleep accounts for brain aging-related increases in anxiety.Communications psychology · 2026Article
- Ventromedial prefrontal cortex activity during extinction recall suggests successful extinction learning via mental imagery.Social cognitive and affective neuroscience · 2026Article
- Intrinsic capacity as an indicator of the risk of depression and anxiety: a prospective cohort study based on the UK Biobank.Frontiers in psychology · 2026Article
- Academic burnout profiles and their correlates: a latent profile analysis of Chinese university students.Frontiers in psychology · 2026Article
- Article
- Physical activity motivation is inversely associated with anxiety: a cross-sectional serial mediation analysis involving smartphone addiction symptoms and sleep quality in medical undergraduates.Frontiers in psychology · 2026Article
- Sleep Disturbance in Adults with Type 2 Diabetes: Psychosocial Factors Across Anxiety Symptom Groups.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Estradiol and non-REM sleep attenuate physiological and emotional responses to social-evaluative stress in healthy women.BMC medicine · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Are you feeling anxious? Did you sleep poorly last night? Sleep disruption is a recognized feature of all anxiety disorders. Here, we investigate the basic brain mechanisms underlying the anxiogenic impact of sleep loss. Additionally, we explore whether subtle, societally common reductions in sleep trigger elevated next-day anxiety. Finally, we examine what it is about sleep, physiologically, that provides such an overnight anxiety-reduction benefit. We demonstrate that the anxiogenic impact of sleep loss is linked to impaired medial prefrontal cortex activity and associated connectivity with extended limbic regions. In contrast, non-rapid eye movement (NREM) slow-wave oscillations offer an ameliorating, anxiolytic benefit on these brain networks following sleep. Of societal relevance, we establish that even modest night-to-night reductions in sleep across the population predict consequential day-to-day increases in anxiety. These findings help contribute to an emerging framework explaining the intimate link between sleep and anxiety and further highlight the prospect of non-rapid eye movement sleep as a therapeutic target for meaningfully reducing anxiety.
Indexed as
Identifiers
31685950What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.