ArticleScientific reports2019
Bisphenol S rapidly depresses heart function through estrogen receptor-β and decreases phospholamban phosphorylation in a sex-dependent manner.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Vascular Endocrine-Disrupting Effects of Bisphenol F and Bisphenol S on Human Umbilical Artery.Journal of xenobiotics · 2026Article
- The cannabinoid receptor 2 is an in vivo receptor of bisphenol A during bone formation.Journal of hazardous materials · 2026Article
- Article
- Induction of fibrosis following exposure to bisphenol A and its analogues in 3D human uterine leiomyoma cultures.Journal of hazardous materials · 2024Article
- Perimenopause Decreases SERCA2a Activity in the Hearts of a Mouse Model of Ovarian Failure.Biomolecules · 2024Article
- Comparative cardiotoxicity assessment of bisphenol chemicals and estradiol using human induced pluripotent stem cell-derived cardiomyocytes.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Article
- Combination of Bisphenol A and Its Emergent Substitute Molecules Is Related to Heart Disease and Exerts a Differential Effect on Vascular Endothelium.International journal of molecular sciences · 2023Article
- Bisphenol S Increases Cell Number and Stimulates Migration of Endometrial Epithelial Cells.Journal of the ASEAN Federation of Endocrine Societies · 2023Article
- Characteristics of Bisphenol Cardiotoxicity: Impaired Excitability, Contractility, and Relaxation.Cardiovascular toxicology · 2022Review
- Prenatal exposure to a low dose of BPS causes sex-dependent alterations to vascular endothelial function in adult offspring.Frontiers in toxicology · 2022Article
- Trans-disciplinary diagnosis for an in-depth reform of regulatory expertise in the field of environmental toxicology and security.Toxicological research · 2021Review
- Interplay Between Endocrine Disruptors and Immunity: Implications for Diseases of Autoreactive Etiology.Frontiers in pharmacology · 2021Review
- Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes.Birth defects research · 2020Review
- Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability.International journal of environmental research and public health · 2019Review
- Sex-specific associations between urinary bisphenols concentrations during pregnancy and problematic child behaviors at age 2 years.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The health effects of the endocrine disruptor Bisphenol A (BPA) led to its partial replacement with Bisphenol S (BPS) in several products including food containers, toys, and thermal paper receipts. The acute effects of BPS on myocardial contractility are unknown. We perfused mouse hearts from both sexes for 15 min with physiologically relevant doses of BPS or BPA. In females BPS (1 nM) decreased left ventricular systolic pressure by 5 min, whereas BPA (1 nM) effects were delayed to 10 min. BPS effects in male mice were attenuated. In both sexes ER-β antagonism abolished the effects of BPS. Cardiac myofilament function was not impacted by BPS or BPA in either sex, although there were sex-dependent differences in troponin I phosphorylation. BPS increased phospholamban phosphorylation at S16 only in female hearts, whereas BPA reduced phosphorylation in both sexes. BPA decreased phospholamban phosphorylation at T17 in both sexes while BPS caused dephosphorylation only in females. This is the first study to compare sex differences in the acute myocardial response to physiologically relevant levels of BPS and BPA, and demonstrates a rapid ability of both to depress heart function. This study raises concerns about the safety of BPS as a replacement for BPA.
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