SynthesisNutrition & diabetes2019
Double or hybrid diabetes: A systematic review on disease prevalence, characteristics and risk factors.
Synthesis in Nutrition & diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04813146 (Role of Synchronized Lifestyle Modification Program on Diabetic Peripheral Neuropathy Patients Taking Oral Hypoglycemics and GLP-1 Analogues), which is not on this map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Synchronized Lifestyle Modification Program on Diabetic Peripheral Neuropathy Patients Taking Oral Hypoglycemics and GLP-1 Analogues
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Choice of Bariatric Surgery in Patients with Obesity and Type 1 Diabetes Mellitus? an Up-to-Date Systematic Review.Obesity surgery · 2022Pooled it
- Effectiveness of Disease-Specific mHealth Apps in Patients With Diabetes Mellitus: Scoping Review.JMIR mHealth and uHealth · 2021Pooled it
- Article
- Targeting the Ras-Ral Signaling Axis in Type 2 Diabetes Mellitus: A Dual-Modulation Approach to Correcting Insulin Resistance and β-Cell Dysfunction.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Islet Autoantibody and Beta Cell Secretory Status at Diagnosis in Young Bangladeshi with Phenotypically Type 2 Diabetes.Journal of the ASEAN Federation of Endocrine Societies · 2026Article
- Evaluation of the Comparative Efficacy of an Ayurvedic Formulation (JMIR research protocols · 2026Article
- Article
- Metabolic dysfunction-associated steatotic liver disease is associated with vascular dysfunction in type 1 diabetes.Cardiovascular diabetology · 2026Article
- Quantifying lifetime risk for 1,401 infectious diseases across the diabetes spectrum using a Bayesian approach.BMC medicine · 2026Article
- microRNA-210 in red blood cells differentially regulates vascular endothelial function between type 1 and type 2 diabetes.Physiological reports · 2026Article
- Prevalence and characteristics of overweight/obesity in children newly diagnosed with type 1 diabetes in Kuwait.Frontiers in endocrinology · 2026Article
- Creating an adolescent intensive health behavior and lifestyle treatment for type 1 diabetes: Feedback from the target population.Obesity pillars · 2025Article
- The pathophysiological link between type 1 diabetes and MASLD: insights into insulin resistance and liver dysfunction.Journal of endocrinological investigation · 2025Review
- Maternal immune-mediated conditions and ADHD risk in offspring.BMC medicine · 2025Article
- Prevalence of Mortality and Vascular Complications in Older Patients with Diabetes in Korea.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- Targeting Mitochondrial Dysfunction to Prevent Endothelial Dysfunction and Atherosclerosis in Diabetes: Focus on the Novel Uncoupler BAM15.International journal of molecular sciences · 2025Review
- From inequalities to solutions: an explanatory sequential study on type 2 diabetes health services utilization.BMC health services research · 2025Article
- Hyperinsulinemic male LEW.1WR1 rats show early signs of impaired liver metabolism.Experimental and molecular pathology · 2025Article
- Importance of etiologies of secondary diabetes: How often do we think off in clinical practice?World journal of clinical cases · 2025Article
- Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes.Cardiovascular diabetology · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus is a worldwide epidemic affecting the health of millions of people. While type 1 diabetes (T1D) is caused by autoimmune destruction of the insulin-producing beta cells of the pancreas, type 2 diabetes (T2D) results from a combination of insulin resistance and beta cell insulin secretory defect. Clear definition and diagnosis of these two types of diabetes has been increasing more and more difficult, leading to the inclusion of a new category, namely double or hybrid diabetes (DD) that demonstrates symptoms of both T1D and T2D via the accelerator hypothesis. In this review, we discuss the worldwide prevalence of DD, its main physiological characteristics, including beta-cell autoimmunity, insulin resistance, and cardiovascular disease, the main risk factors of developing DD, mainly genetics, obesity and lifestyle choices, as well as potential treatments, such as insulin titration, metformin and behavioural modifications. Increasing awareness of DD among the general population and primary care practitioners is necessary for successfully treating this complex, hybrid disease in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.