ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Pulsed Facilitation of Corticospinal Excitability by the Sensorimotor μ-Alpha Rhythm.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Frequency-specific modulation of motor cortical excitability by transcranial alternating current stimulation.Journal of neuroengineering and rehabilitation · 2025Trial
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- Induction of LTD-like corticospinal plasticity by low-frequency rTMS depends on pre-stimulus phase of sensorimotor μ-rhythm.Brain stimulationTrial
- Distinct electroencephalography alpha-band rhythms map macroscale brain gradients.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- From Oscillations to Brain States: Real-Time EEG-TMS for Adaptive Neuromodulation.Bioengineering (Basel, Switzerland) · 2026Review
- Aperiodic Brain Activity Modulates Corticospinal Excitability.Neuroscience bulletin · 2026Article
- Primary Somatosensory to Motor Cortex Microstructural Connectivity Predicts the Mu-Rhythm Phase Effect on Corticospinal Excitability: An EEG-TMS Study.Human brain mapping · 2026Article
- Mu-Rhythm Phase Modulates Cortical Reactivity to Subthreshold TMS: A TMS-EEG Study.Bioengineering (Basel, Switzerland) · 2026Article
- Bayesian Temporal Prediction: A Robust Algorithm for Real-Time EEG Phase-Dependent Brain Stimulation.IEEE transactions on bio-medical engineering · 2026Article
- Plasticity of interhemispheric motor cortex connectivity induced by brain state-dependent cortico-cortical paired-associative stimulation.Scientific reports · 2025Article
- Non-invasive brain stimulation to modulate neural activity in Parkinson's disease.NPJ Parkinson's disease · 2025Review
- μ-Transcranial Alternating Current Stimulation Induces Phasic Entrainment and Plastic Facilitation of Corticospinal Excitability.The European journal of neuroscience · 2025Article
- Article
- Real-time TMS-EEG for brain state-controlled research and precision treatment: a narrative review and guide.Journal of neural engineering · 2024Review
- Personalized whole-brain activity patterns predict human corticospinal tract activation in real-time.bioRxiv : the preprint server for biology · 2024Article
- Signal switching may enhance processing power of the brain.Trends in cognitive sciences · 2024Review
- Abnormalities in both stimulus-induced and baseline MEG alpha oscillations in the auditory cortex of children with Autism Spectrum Disorder.Brain structure & function · 2024Article
- Closed-Loop Brain Stimulation.Biological psychiatry · 2024Review
- Alpha-band fluctuations represent behaviorally relevant excitability changes as a consequence of top-down guided spatial attention in a probabilistic spatial cueing design.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Interactions of transcranial magnetic stimulation with brain oscillations: a narrative review.Frontiers in systems neuroscience · 2024Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Alpha oscillations (8-14 Hz) are assumed to gate information flow in the brain by means of pulsed inhibition; that is, the phasic suppression of cortical excitability and information processing once per alpha cycle, resulting in stronger net suppression for larger alpha amplitudes due to the assumed amplitude asymmetry of the oscillation. While there is evidence for this hypothesis regarding occipital alpha oscillations, it is less clear for the central sensorimotor μ-alpha rhythm. Probing corticospinal excitability via transcranial magnetic stimulation (TMS) of the primary motor cortex and the measurement of motor evoked potentials (MEPs), we have previously demonstrated that corticospinal excitability is modulated by both amplitude and phase of the sensorimotor μ-alpha rhythm. However, the direction of this modulation, its proposed asymmetry, and its underlying mechanisms remained unclear. We therefore used real-time EEG-triggered single- and paired-pulse TMS in healthy humans of both sexes to assess corticospinal excitability and GABA-A-receptor mediated short-latency intracortical inhibition (SICI) at rest during spontaneous high amplitude μ-alpha waves at different phase angles (peaks, troughs, rising and falling flanks) and compared them to periods of low amplitude (desynchronized) μ-alpha. MEP amplitude was facilitated during troughs and rising flanks, but no phasic suppression was observed at any time, nor any modulation of SICI. These results are best compatible with sensorimotor μ-alpha reflecting asymmetric pulsed facilitation but not pulsed inhibition of motor cortical excitability. The asymmetric excitability with respect to rising and falling flanks of the μ-alpha cycle further reveals that voltage differences alone cannot explain the impact of phase.
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