Evidence map›Paper›PMID 31685654›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

The NGF

Giovanna Testa, Marco Mainardi, Chiara Morelli, Francesco Olimpico, Laura Pancrazi, Carla Petrella, Cinzia Severini, Rita Florio, Francesca Malerba, Antonia Stefanov and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. The development of somatosensory neurons: Insights into pain and itch.Current topics in developmental biology · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Giovanna TestaBio@SNS, Scuola Normale Superiore, 56124 Pisa, Italy.
Marco MainardiBio@SNS, Scuola Normale Superiore, 56124 Pisa, Italy.ORCID 0000-0003-2001-1287
Chiara MorelliEuropean Molecular Biology Laboratory (EMBL), 00015 Monterotondo (Rome), Italy.
Francesco OlimpicoBio@SNS, Scuola Normale Superiore, 56124 Pisa, Italy.
Laura PancraziBio@SNS, Scuola Normale Superiore, 56124 Pisa, Italy.
Carla PetrellaInstitute of Biochemistry and Cell Biology (IBBC), CNR, DOS Policlinico Umberto I, 00161 Rome, Italy.ORCID 0000-0003-0651-1816
Cinzia SeveriniInstitute of Biochemistry and Cell Biology (IBBC), CNR, DOS Policlinico Umberto I, 00161 Rome, Italy.ORCID 0000-0002-6932-704X
Rita FlorioNeurotrophins and Neurodegenerative Diseases Laboratory, Rita Levi-Montalcini European Brain Research Institute (EBRI), 00161 Rome, Italy, and.
Francesca MalerbaNeurotrophins and Neurodegenerative Diseases Laboratory, Rita Levi-Montalcini European Brain Research Institute (EBRI), 00161 Rome, Italy, and.
Antonia StefanovInstitute of Neuroscience, National Research Council (CNR), 56124 Pisa, Italy.
Enrica StrettoiInstitute of Neuroscience, National Research Council (CNR), 56124 Pisa, Italy.
Rossella BrandiNeurotrophins and Neurodegenerative Diseases Laboratory, Rita Levi-Montalcini European Brain Research Institute (EBRI), 00161 Rome, Italy, and.
Ivan ArisiNeurotrophins and Neurodegenerative Diseases Laboratory, Rita Levi-Montalcini European Brain Research Institute (EBRI), 00161 Rome, Italy, and.
Paul HeppenstallEuropean Molecular Biology Laboratory (EMBL), 00015 Monterotondo (Rome), Italy.
Mario CostaInstitute of Neuroscience, National Research Council (CNR), 56124 Pisa, Italy.
Simona CapsoniBio@SNS, Scuola Normale Superiore, 56124 Pisa, Italy, antonino.cattaneo@sns.it simona.capsoni@sns.it.
Antonino CattaneoBio@SNS, Scuola Normale Superiore, 56124 Pisa, Italy, antonino.cattaneo@sns.it simona.capsoni@sns.it.
Scuola Normale Superiore · ITEuropean Brain Research Institute · ITNational Research Council · ITPoliclinico Umberto I · ITEuropean Molecular Biology Laboratory · ITEuropean Molecular Biology Organization · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nerve growth factor (NGF) is a key mediator of nociception, acting during the development and differentiation of dorsal root ganglion (DRG) neurons, and on adult DRG neuron sensitization to painful stimuli. NGF also has central actions in the brain, where it regulates the phenotypic maintenance of cholinergic neurons. The physiological function of NGF as a pain mediator is altered in patients with Hereditary Sensory and Autonomic Neuropathy type V (HSAN V), caused by the 661C>T transition in the

Indexed as

CognitionNociceptionAnimalsBehavior, AnimalFemaleGanglia, SpinalGene Knock-In TechniquesHereditary Sensory and Autonomic NeuropathiesHumansMaleMiceMice, TransgenicMutationMutation, MissenseNerve Growth FactorPain MeasurementNerve Growth FactorNGF protein, humanallodyniadorsal root gangliahereditary sensory and autonomic neuropathy type Vlearning and memorynerve growth factorskin innervation

Identifiers

PMID31685654
PMCPMC6891056
OpenAlexW2988325021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.