SynthesisPublic health nutrition2020
Lower circulating zinc and selenium levels are associated with an increased risk of asthma: evidence from a meta-analysis.
Synthesis in Public health nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06869798 (EFFECTIVENESS OF ZINC AS AN ADJUVANT TO STANDARD THERAPY VERSUS STANDARD THERAPY ALONE IN CHILDREN), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of zinc as an adjuvant to standard therapy versus standard therapy alone in children (5-10 years) with moderate persistent asthma
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Identifying risk factors for COPD and adult-onset asthma: an umbrella review.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- The Modern Environment and Childhood Asthma: The Role of Air Pollution and Heavy Metal Exposure.Current allergy and asthma reports · 2026Review
- Nutrition as a Modifiable Factor in Optimizing Respiratory Health: Evidence from Pulmonary Function Tests.Children (Basel, Switzerland) · 2026Review
- Enhancing antioxidant capacity and reducing asthma risk: the impact of zinc and iron on molecular pathways.Clinical and experimental medicine · 2025Article
- Nutraceuticals Against Oxidative Stress in Allergic Diseases.Biomolecules · 2025Review
- The Role of Zinc in Pediatric Asthma and Allergic Rhinitis: Mechanisms and Clinical Implications.Nutrients · 2025Review
- The association between the composite dietary antioxidant index and asthma in US children aged 3-18 years: a cross-sectional study from NHANES.Scientific reports · 2024Article
- Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- The Role of Diet and Nutrition in Allergic Diseases.Nutrients · 2023Review
- Article
- The Role of Zinc in the Pathogenesis of Lung Disease.Nutrients · 2022Review
- Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases.Frontiers in nutrition · 2022Review
- Association between Glucose-6-Phosphate Dehydrogenase Deficiency and Asthma.Journal of clinical medicine · 2021Article
- Mineral Micronutrients in Asthma.Nutrients · 2021Review
- Evaluation of blood and tooth element status in asthma cases: a preliminary case-control study.BMC pulmonary medicine · 2021Article
- Review - Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics.Journal of asthma and allergy · 2021Review
- Zinc transporter SLC39A7 relieves zinc deficiency to suppress alternative macrophage activation and impairment of phagocytosis.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrevious studies evaluating the associations of circulating Zn and Se levels with asthma have produced inconsistent results. Therefore, we conducted a meta-analysis to summarize and quantitatively synthesize the evidence from observational research.
designMeta-analysis.
settingWe searched PubMed, Web of Science and Scopus databases up to May 2019 for relevant available articles. Random-effects model was adopted to estimate the pooled standardized mean difference (SMD) with 95 % CI. Meta-regression analysis and 'leave-one-out' sensitivity analysis were used to assess heterogeneity.
participantsThe meta-analysis focused on general populations.
resultsA total of twenty-six studies for Zn and forty studies for Se were included in the meta-analysis. The overall analyses identified that asthma patients had lower Zn (SMD = -0·40; 95 % CI -0·77, -0·03; I2 = 94·1 %) and Se (SMD = -0·32; 95 % CI -0·48, -0·17; I2 = 90·9 %) levels in serum or plasma compared with healthy controls. After removing the studies that contributed to the heterogeneity, the pooled SMD were -0·26 (95 % CI -0·40, -0·13; I2 = 37·42 %) for Zn and -0·06 (95 % CI -0·13, 0·02; I2 = 43·54 %) for Se.
conclusionsLower circulating Zn and Se levels might be associated with an increased risk of asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.