ArticleCardiovascular ultrasound2019
Global longitudinal strain as an Indicator of cardiac Iron overload in thalassemia patients.
Article in Cardiovascular ultrasound, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Speckle tracking echocardiography and β-thalassemia major. A systematic review.Annals of hematology · 2024Pooled it
- Global longitudinal strain for detection of cardiac iron overload in patients with thalassemia: a meta-analysis of observational studies with individual-level participant data.Cardiovascular ultrasound · 2022Pooled it
- Distinct Echocardiographic Phenotypes in Primary vs. Secondary Iron Overload Cardiomyopathy: A Pilot Study on Myocardial Work Indices.Medical sciences (Basel, Switzerland) · 2026Article
- Multimodal evidence chain of iron overload, inflammation, and dysfunction: an integrated predictive model of early cardiac injury in pediatric transfusion-dependentFrontiers in cardiovascular medicine · 2026Article
- Alterations in iron status predict cardiac response to blood transfusion in β-thalassemia major.Scientific reports · 2025Article
- Cardiac Dysfunction in β-Thalassemia: A Narrative Review.Research in heart yield and translational medicine · 2025Review
- Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis.Frontiers in cardiovascular medicine · 2025Article
- Global and regional cardiac magnetic resonance feature tracking left ventricular strain analysis in assessing early myocardial disease in β thalassemia major patients.Journal of cardiovascular imaging · 2024Article
- Research on the clinical factors of cardiac iron deposition in children with beta-thalassemia major.European journal of pediatrics · 2024Article
- Four‑Dimensional Echocardiographic Evaluation of Cardiac Iron Overload in Patients with Beta-Thalassemia Major.Cardiovascular toxicology · 2024Observational
- Role of feature tracking cardiac magnetic resonance imaging in early detection of cardiac dysfunction in β-thalassemia patients recovered from COVID-19: A cross-sectional study.Health science reports · 2024Article
- Left Ventricular Myocardial Dysfunction Evaluation in Thalassemia Patients Using Echocardiographic Radiomic Features and Machine Learning Algorithms.Journal of digital imaging · 2023Article
- Speckle tracking echocardiography-derived left ventricular global longitudinal strain in ex-thalassaemics.PloS one · 2023Article
- Echocardiographic Advances in Dilated Cardiomyopathy.Journal of clinical medicine · 2021Review
- Role of CMR feature-tracking derived left ventricular strain in predicting myocardial iron overload and assessing myocardial contractile dysfunction in patients with thalassemia major.European radiology · 2021Article
- Left ventricular deformation mechanics over time in patients with thalassemia major with and without iron overload.BMC cardiovascular disorders · 2021Article
- Abnormal diastolic function and Global longitudinal strain in patients with Thalassemia Major on long term chelation therapy.The international journal of cardiovascular imaging · 2021Article
- Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms.Frontiers in cell and developmental biology · 2021Review
- Occult Kidney Dysfunction in Children With Transfusion-Dependent Thalassemia.Frontiers in pediatrics · 2021Article
- Myocardial longitudinal strain as the first herald of cardiac impairment in very early iron overload state: an echocardiography and biosusceptometry study on beta-thalassemia patients.American journal of cardiovascular disease · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveCardiac involvement due to iron overload is the most common cause of morbidity and mortality in patients with thalassemia, and many patients remain asymptomatic until the late stages. Therefore, early detection of heart problems in such patients at subclinical stages can improve the prognosis of these patients. We investigated the role of speckled tracking (SI) and tissue Doppler echocardiography (TDI) in early detection of iron overload in these patients.
methods52 thalassemic patients who were receiving regular blood transfusion with normal global LV function were examined by two- and three-dimensional echocardiography. Cardiac MRI was done and T2* images were considered as the non-invasive gold standard for evaluating cardiac iron deposition. Serum ferritin level was assessed and the relationships between serum ferritin levels and echo finding with cardiac MRI T
resultsNo significant relationship was seen between serum ferritin levels and cardiac MRI T
conclusionWhile serum ferritin level and ejection fraction are not useful candidates, GLS may be used as a valuable marker to screen thalassemia patients for myocardial iron deposition, using a cut off value below - 19.5. This approach may facilitate the cardiac follow up, reduce the costs, and contribute to preventing deterioration of cardiac function in countries with limited availability of cardiac MRI.
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