ArticleCardiovascular diabetology2019
Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart.
Article in Cardiovascular diabetology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 144 citations in OpenAlex.
- Association between triglyceride glucose index and arterial stiffness and coronary artery calcification: a systematic review and exposure-effect meta-analysis.Cardiovascular diabetology · 2023Pooled it
- Triglyceride and Glucose Index and Sex Differences in Relation to Major Adverse Cardiovascular Events in Hypertensive Patients Without Diabetes.Frontiers in endocrinology · 2021Trial
- Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation.The Journal of physiology · 2026Article
- Prognostic value of the triglyceride-glucose index combined with atherogenic index of plasma for all-cause mortality in critically ill patients with chronic heart failure: a machine learning-driven retrospective cohort study.Lipids in health and disease · 2026Article
- Relations of Artificial Intelligence Vascular Age With Cardiometabolic Disease Progression: The Framingham Heart Study.Journal of the American Heart Association · 2025Article
- Triglyceride-glucose index predicts the mortality risk among incident peritoneal dialysis patients in a cohort study.Scientific reports · 2025Observational
- Estimated glucose disposal rate and the risk of major adverse cardio-cerebrovascular outcomes and mortality in patients undergoing percutaneous coronary intervention: a retrospective cohort study.European journal of medical research · 2025Article
- Metabolic and vascular insulin resistance: partners in the pathogenesis of cardiovascular disease in diabetes.American journal of physiology. Heart and circulatory physiology · 2025Review
- The association between the triglyceride‒glucose index and short-term mortality in ICU patients with sepsis-associated acute kidney injury.BMC infectious diseases · 2025Article
- Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database.Scientific reports · 2025Observational
- Association between triglyceride-glucose index and all-cause mortality in patients with congestive heart failure and atrial fibrillation.Frontiers in cardiovascular medicine · 2025Article
- Article
- Association between all-cause mortality and triglyceride glucose body mass index among critically ill patients with sepsis: a retrospective cohort investigation.Lipids in health and disease · 2024Article
- Correlation of the triglyceride-glucose index and heart rate with 28-day all-cause mortality in severely ill patients: analysis of the MIMIC-IV database.Lipids in health and disease · 2024Article
- Vital Predictive and Prognostic Roles of Triglyceride-Glucose Index in Women With Acute Myocardial Infarction: A Retrospective Cohort Study.Health science reports · 2024Article
- Skin Microvascular Dysfunction in Type 2 Diabetes Mellitus Using Laser Speckle Contrast Analysis and Association with Carotid Intima-Media Thickness.Journal of clinical medicine · 2024Article
- U-shaped association between triglyceride-glucose index and all-cause mortality among critically ill pediatrics: a population-based retrospective cohort study.Cardiovascular diabetology · 2024Observational
- Association of TyG index and central obesity with hypertension in middle-aged and elderly Chinese adults: a prospective cohort study.Scientific reports · 2024Article
- The triglyceride-glucose index: a novel predictor of stroke and all-cause mortality in liver transplantation recipients.Cardiovascular diabetology · 2024Article
- Triglyceride-glucose index predicts future chronic kidney disease development in all populations, including normotensive and isolated diastolic hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes.
methodsCross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent population-based studies, the Study of Health in Pomerania (SHIP-TREND-0) and KORA FF4 Study. FG, FI, HOMA-IR, 2HG and 2HI, as well as glucose tolerance categories, were analyzed for associations with heart and arterial parameters using multivariable-adjusted linear regression models.
resultsIn total, 390 individuals (39%) had prediabetes (isolated impaired fasting glucose, isolated glucose tolerance or both), and 49 (4.9%) were found to have unknown type 2 diabetes. In the multivariable-adjusted analysis, positive linear associations of FG, FI, HOMA-IR, 2HG and 2HI with arterial stiffness index and left ventricular wall-thickness and concentricity and inverse linear associations with left ventricular end-diastolic volume were observed. A 1 mmol/l higher FG was associated with a 1.18 ml/m
conclusionsOur findings suggest that higher glucose levels in the prediabetic range and insulin resistance might lead to higher arterial stiffness and concentric remodeling of the heart.
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