Evidence map›Paper›PMID 31684921›Full record

ArticleBMC musculoskeletal disorders2019

A consensus-based process identifying physical therapy and exercise treatments for patients with degenerative meniscal tears and knee OA: the TeMPO physical therapy interventions and home exercise program.

Clare E Safran-Norton, James K Sullivan, James J Irrgang, Hannah M Kerman, Kim L Bennell, Gary Calabrese, Leigh Dechaves, Brian Deluca, Alexandra B Gil, Madhuri Kale and 6 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03059004 nacompletednot on this map

Treatment of Meniscal Problems in Osteoarthritis

TypeinterventionalSponsorBrigham and Women's HospitalRan2018 to 2024Enrolled879ConditionsMeniscal Degeneration, Osteoarthritis, KneeArmsTeMPO Home Exercise Program, Motivational SMS Messages, In-Clinic Topical Therapy, In-Clinic Exercise Therapy
NCT05131048 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effects of Home-based Hip Strengthening Exercises on Pain, Range of Motion and Functional Disability in Knee Osteoarthritis Patients: a Randomized Controlled Trial

TypeinterventionalSponsorUniversity of LahoreRan2021 to 2022Enrolled90ConditionsKnee OsteoarthritisArmsconventional group, experimental group
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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  8. Quercetin attenuates the symptoms of osteoarthritisMolecular medicine reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Clare E Safran-NortonOrthopaedic and Arthritis Center for Outcomes Research (OrACORe) and Policy and Innovation eValuation in Orthopedic Treatments (PIVOT), Department of Orthopaedic Surgery, Brigham and Women's Hospital, 75 Francis Street, BTM 5016, Boston, MA, 02115, USA.
James K SullivanOrthopaedic and Arthritis Center for Outcomes Research (OrACORe) and Policy and Innovation eValuation in Orthopedic Treatments (PIVOT), Department of Orthopaedic Surgery, Brigham and Women's Hospital, 75 Francis Street, BTM 5016, Boston, MA, 02115, USA.
James J IrrgangDepartment of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Hannah M KermanOrthopaedic and Arthritis Center for Outcomes Research (OrACORe) and Policy and Innovation eValuation in Orthopedic Treatments (PIVOT), Department of Orthopaedic Surgery, Brigham and Women's Hospital, 75 Francis Street, BTM 5016, Boston, MA, 02115, USA.
Kim L BennellCentre for Health, Exercise and Sports Medicine, School of Health Sciences, University of Melbourne, Melbourne, Australia.
Gary CalabreseDepartment of Rehabilitation and Sports Therapy, Cleveland Clinic, Cleveland, OH, USA.
Leigh DechavesDepartment of Rehabilitation Services - Physical and Occupational Therapy, Brigham and Women's Hospital, Boston, MA, USA.
Brian DelucaUBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Alexandra B GilDepartment of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Madhuri KaleDepartment of Rehabilitation Services - Physical and Occupational Therapy, Brigham and Women's Hospital, Boston, MA, USA.
Brittney Luc-HarkeyOrthopaedic and Arthritis Center for Outcomes Research (OrACORe) and Policy and Innovation eValuation in Orthopedic Treatments (PIVOT), Department of Orthopaedic Surgery, Brigham and Women's Hospital, 75 Francis Street, BTM 5016, Boston, MA, 02115, USA.
Faith SelzerOrthopaedic and Arthritis Center for Outcomes Research (OrACORe) and Policy and Innovation eValuation in Orthopedic Treatments (PIVOT), Department of Orthopaedic Surgery, Brigham and Women's Hospital, 75 Francis Street, BTM 5016, Boston, MA, 02115, USA.
Derek SopleDepartment of Rehabilitation Services - Physical and Occupational Therapy, Brigham and Women's Hospital, Boston, MA, USA.
Peter TonsolineUBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Elena LosinaOrthopaedic and Arthritis Center for Outcomes Research (OrACORe) and Policy and Innovation eValuation in Orthopedic Treatments (PIVOT), Department of Orthopaedic Surgery, Brigham and Women's Hospital, 75 Francis Street, BTM 5016, Boston, MA, 02115, USA.
Jeffrey N KatzOrthopaedic and Arthritis Center for Outcomes Research (OrACORe) and Policy and Innovation eValuation in Orthopedic Treatments (PIVOT), Department of Orthopaedic Surgery, Brigham and Women's Hospital, 75 Francis Street, BTM 5016, Boston, MA, 02115, USA. jnkatz@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-2104-4670
Brigham and Women's Hospital · USUniversity at Buffalo, State University of New York · USUniversity of Pittsburgh · USBoston University · USCleveland Clinic · USThe University of Melbourne · AU

Funding

Treatment of Meniscal Problems in Osteoarthritis: TeMPOU01AR071658 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KATZ, JEFFREY NEIL · 2017 to 2022
$4.1M
NIAMS NIH HHS U01 AR071658NIAMS NIH HHS U01AR071658
6 · The paper itself

Abstract

backgroundKnee osteoarthritis (OA) is prevalent and often associated with meniscal tear. Physical therapy (PT) and exercise regimens are often used to treat OA or meniscal tear, but, to date, few programs have been designed specifically for conservative treatment of meniscal tear with concomitant knee OA. Clinical care and research would be enhanced by a standardized, evidence-based, conservative treatment program and the ability to study the effects of the contextual factors associated with interventions for patients with painful, degenerative meniscal tears in the setting of OA. This paper describes the process of developing both a PT intervention and a home exercise program for a randomized controlled clinical trial that will compare the effectiveness of these interventions for patients with knee pain, meniscal tear and concomitant OA.

methodsThis paper describes the process utilized by an interdisciplinary team of physical therapists, physicians, and researchers to develop and refine a standardized in-clinic PT intervention, and a standardized home exercise program to be carried out without PT supervision. The process was guided in part by Medical Research Council guidance on intervention development.

resultsThe investigators achieved agreement on an in-clinic PT intervention that included manual therapy, stretching, strengthening, and neuromuscular functional training addressing major impairments in range of motion, musculotendinous length, muscle strength and neuromotor control in the major muscle groups associated with improving knee function. The investigators additionally achieved agreement on a progressive, protocol-based home exercise program (HEP) that addressed the same major muscle groups. The HEP was designed to allow patients to perform and progress the exercises without PT supervision, utilizing minimal equipment and a variety of methods for instruction. DISCUSSION: This multi-faceted in-clinic PT program and standardized HEP provide templates for in-clinic and home-based care for patients with symptomatic degenerative meniscal tear and concomitant OA. These interventions will be tested as part of the Treatment of Meniscal Tear in Osteoarthritis (TeMPO) Trial.

trial registrationThe TeMPO Trial was first registered at clinicaltrials.gov with registration No. NCT03059004 on February 14, 2017. TeMPO was also approved by the Institutional Review Board at Partners HealthCare/Brigham and Women's Hospital.

Indexed as

Evidence-Based MedicineExercise TherapyHome Care Services, Hospital-BasedOsteoarthritis, KneeTibial Meniscus InjuriesAdultConsensusFemaleHumansMaleMiddle AgedPatient Care TeamPractice Guidelines as TopicRandomized Controlled Trials as TopicResearch DesignHome exercise programMeniscal tearOsteoarthritisPhysical therapyRandomized trial

Identifiers

PMID31684921
PMCPMC6830005
OpenAlexW2985676785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.